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Systematic Review on the Safety and Efficacy of Herbal Medicine for the Treatment of Vascular Dementia
Man, Sui Cheung; Chan, Kam Wa; Lu, Jia-Hong; Durairajan, Siva Sundara Kumar; Liu, Liang-Feng; Li, Min
2012
Source PublicationEvidence-Based Complementary and Alternative Medicine
ISSN1741-427X
Volume2012
Abstract

We present a systematic review of existing research that aims to assess the efficacy and safety of herbal medications (HM), as either monotherapy or adjunct to orthodox medications (OM), mainly comprised of cholinesterase inhibitors, for vascular dementia (VaD). We included 47 studies conducted in mainland China, each testing different HM. Of 43 HM monotherapy studies, 37 reported HM to be significantly better than OM or placebo; six reported similar efficacy between HM and OM. All four HM adjuvant studies reported significant efficacy. No major adverse events for HM were reported. Heterogeneity in diagnostic criteria, interventions and outcome measures hindered comprehensive data analysis. Studies suggested that HM can be a safe and effective treatment for VaD, either alone or in conjunction with OM. However, methodological flaws in the design of the studies limited the extent to which the results could be interpreted. Thirty most commonly used herbal constituents, including Rhizoma Chuanxiong (Chuanxiong in Chinese), Radix Polygoni Multiflori (Heshouwu in Chinese) and Radix Astragali (Huangqi in Chinese). were ranked. Further multi-center trials with large sample sizes, high methodological quality and standardized HM ingredients are necessary for clinical recommendations to be made.

DOIhttp://dx.doi.org/10.1155/2012/426215
Indexed BySCI
Language英语
WOS Research AreaIntegrative & Complementary Medicine
WOS SubjectIntegrative & Complementary Medicine
WOS IDWOS:000298508600001
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被引频次[WOS]:14   [WOS记录]     [WOS相关记录]
Document TypeJournal article
专题Institute of Chinese Medical Sciences
Corresponding AuthorLi, Min
AffiliationHong Kong Baptist Univ, Sch Chinese Med, Kowloon Tong, Hong Kong, Peoples R China.
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GB/T 7714
Man, Sui Cheung,Chan, Kam Wa,Lu, Jia-Hong,et al. Systematic Review on the Safety and Efficacy of Herbal Medicine for the Treatment of Vascular Dementia[J]. Evidence-Based Complementary and Alternative Medicine,2012,2012.
APA Man, Sui Cheung,Chan, Kam Wa,Lu, Jia-Hong,Durairajan, Siva Sundara Kumar,Liu, Liang-Feng,&Li, Min.(2012).Systematic Review on the Safety and Efficacy of Herbal Medicine for the Treatment of Vascular Dementia.Evidence-Based Complementary and Alternative Medicine,2012.
MLA Man, Sui Cheung,et al."Systematic Review on the Safety and Efficacy of Herbal Medicine for the Treatment of Vascular Dementia".Evidence-Based Complementary and Alternative Medicine 2012(2012).
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