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Naturally occurring homoisoflavonoids and their pharmacological activities
Lin, Li-Gen1; Liu, Qian-Yu1; Ye, Yang2
2014-08
Source PublicationPlanta Medica
ISSN0032-0943
Volume80Issue:13Pages:1053-1066
Abstract

Homoisoflavonoids, a special subclass of flavonoids, are rarely found in nature, mainly existing in Fabaceae and Asparagaceae families and being less common in Polygonaceae, Portulacaceae, Orchidaceae, and Gentianaceae families. Until now, approximately 240 natural occurring homoisoflavonoids have been identified from roots, barks, heartwood, bulbs, leaves, and seeds of the plants from the above mentioned families, which have often been used in traditional medicine. Homoisoflavonoids have been reported with a broad range of bioactivities, including anti-microbial, anti-mutagenic, anti-oxidant, immunomodulatory, anti-diabetic, cytotoxic, anti-angiogenic, vasorelaxant, and anti-inflammatory effects. To organize this review, the homoisoflavonoids were classified into five groups based on their structures: sappanin-type (I), scillascillin-type (II), brazilin-type (III), caesalpin-type (IV), and protosappanin-type (V). The structures of natural occurring homoisoflavonoids are described, and their proposed biosynthetic pathway and recent pharmacological studies are discussed. The main purpose of this review is to provide a comprehensive and up-to-date state of knowledge from phytochemical and pharmacological studies performed on homoisoflavonoids during the past decades. Homoisoflavonoids might have a large potential for further investigations of their bioactivities in order to identify important leads.

KeywordHomoisoflavonoids Phytochemistry Biosynthesis Pharmacological Activities
DOIhttps://doi.org/10.1055/s-0034-1383026
Indexed BySCI
Language英语
WOS Research AreaPlant Sciences ; Pharmacology & Pharmacy ; Integrative & Complementary Medicine
WOS SubjectPlant Sciences ; Chemistry, Medicinal ; Integrative & Complementary Medicine ; Pharmacology & Pharmacy
WOS IDWOS:000341581600001
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被引频次[WOS]:38   [WOS记录]     [WOS相关记录]
Document TypeJournal article
专题Institute of Chinese Medical Sciences
Corresponding AuthorLin, Li-Gen
Affiliation1.State Key Laboratory of Quality Research in Chinese Medicine, Institute of Chinese Medical Sciences, University of Macau, Macau, P. R. China
2.State Key Laboratory of Drug Research, Shanghai Institute of Materia Medica, Chinese Academy of Sciences, Shanghai, P. R. China
First Author AffilicationInstitute of Chinese Medical Sciences
Corresponding Author AffilicationInstitute of Chinese Medical Sciences
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GB/T 7714
Lin, Li-Gen,Liu, Qian-Yu,Ye, Yang. Naturally occurring homoisoflavonoids and their pharmacological activities[J]. Planta Medica,2014,80(13):1053-1066.
APA Lin, Li-Gen,Liu, Qian-Yu,&Ye, Yang.(2014).Naturally occurring homoisoflavonoids and their pharmacological activities.Planta Medica,80(13),1053-1066.
MLA Lin, Li-Gen,et al."Naturally occurring homoisoflavonoids and their pharmacological activities".Planta Medica 80.13(2014):1053-1066.
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