UM  > 中華醫藥研究院
Ghrelin receptor regulates HFCS-induced adipose inflammation and insulin resistance
Ma, X.1,2; Lin, L.2,3; Yue, J.2,4; Pradhan, G.2; Qin, G.1; Minze, L. J.5; Wu, H.6; Sheikh-Hamad, D.6; Smith, C. W.2; Sun, Y.2,7
Source PublicationNutrition and Diabetes

BACKGROUND AND OBJECTIVES: High fructose corn syrup (HFCS) is the most commonly used sweetener in the United States. Some studies show that HFCS consumption correlates with obesity and insulin resistance, while other studies are in disagreement. Owing to conflicting and insufficient scientific evidence, the safety of HFCS consumption remains controversial. SUBJECTS/METHODS: We investigated the metabolic consequences of mice fed a (a) regular diet, (b) ‘Western’ high-fat diet or (c) regular diet supplemented with 8% HFCS in drinking water (to mimic soft drinks) for 10 months. Adipose tissue macrophages (ATMs) have emerged as a major pathogenic factor for obesity and insulin resistance. ATMs consist of proinflammatory F4/ 80 þ CD11c þ macrophages and anti-inflammatory F4/80 þ CD11c macrophages. In this study, we assessed the effects of HFCS on ATMs in intra-abdominal fat. RESULTS: We found that HFCS feeding in mice induced more severe adipose inflammation and insulin resistance than even the higher-calorie-containing ‘Western’ high-fat diet, and these HFCS-induced deleterious effects were independent of calorie intake or body fat content. We showed that similar to ‘Western’ high-fat diet, HFCS triggered a robust increase of both proinflammatory ATMs and anti-inflammatory ATMs in intra-abdominal fat. Remarkably, however, the anti-inflammatory ATMs were much less abundant in HFCS-fed mice than in high-fat-fed mice. Furthermore, we showed that deletion of the ghrelin receptor (growth hormone secretagogue receptor, GHS-R) ameliorates HFCS-induced adipose inflammation and insulin resistance. HFCS-fed GHS-R-null mice exhibit decreased proinflammatory ATMs in intra-abdominal fat, reduced adipose inflammation and attenuated liver steatosis. CONCLUSION: Our studies demonstrate that HFCS has detrimental effects on metabolism, suggesting that dietary guidelines on HFCS consumption for Americans may need to be revisited. GHS-R deletion mitigates the effects of HFCS on adipose inflammation and insulin resistance, suggesting that GHS-R antagonists may represent a novel therapy for insulin resistance.

KeywordGhrelin Receptor Hfcs Macrophages Inflammation Insulin Resistance Liver Steatosis
Indexed BySCI
WOS Research AreaEndocrinology & Metabolism ; Nutrition & Dietetics
WOS SubjectEndocrinology & Metabolism ; Nutrition & Dietetics
WOS IDWOS:000330126700003
Fulltext Access
Citation statistics
Cited Times [WOS]:13   [WOS Record]     [Related Records in WOS]
Document TypeJournal article
CollectionInstitute of Chinese Medical Sciences
Corresponding AuthorSun, Y.
Affiliation1.Division of Endocrinology, Department of Internal Medicine, The First Affiliated Hospital of Zhengzhou University, Zhengzhou, China
2.USDA/ARS Children’s Nutrition Research Center, Department of Pediatrics, Baylor College of Medicine, Houston, TX, USA
3.State Key Laboratory of Quality Research in Chinese Medicine, Institute of Chinese Medical Sciences, University of Macau, Macao, China
4.Department of Reproductive Medicine, Tongji Hospital affiliated to Tongji Medical College, Huazhong Science and Technology University, Wuhan, China
5.Preclinical Model Development Core, The Methodist Hospital Research Institute, Houston, TX, USA
6.Department of Medicine, Baylor College of Medicine, Houston, TX, USA
7.Huffington Center on Aging, Department of Molecular and Cellular Biology, Baylor College of Medicine, Houston, TX, USA
Recommended Citation
GB/T 7714
Ma, X.,Lin, L.,Yue, J.,et al. Ghrelin receptor regulates HFCS-induced adipose inflammation and insulin resistance[J]. Nutrition and Diabetes,2013,3(e99).
APA Ma, X..,Lin, L..,Yue, J..,Pradhan, G..,Qin, G..,...&Sun, Y..(2013).Ghrelin receptor regulates HFCS-induced adipose inflammation and insulin resistance.Nutrition and Diabetes,3(e99).
MLA Ma, X.,et al."Ghrelin receptor regulates HFCS-induced adipose inflammation and insulin resistance".Nutrition and Diabetes 3.e99(2013).
Files in This Item:
There are no files associated with this item.
Related Services
Recommend this item
Usage statistics
Export to Endnote
Google Scholar
Similar articles in Google Scholar
[Ma, X.]'s Articles
[Lin, L.]'s Articles
[Yue, J.]'s Articles
Baidu academic
Similar articles in Baidu academic
[Ma, X.]'s Articles
[Lin, L.]'s Articles
[Yue, J.]'s Articles
Bing Scholar
Similar articles in Bing Scholar
[Ma, X.]'s Articles
[Lin, L.]'s Articles
[Yue, J.]'s Articles
Terms of Use
No data!
Social Bookmark/Share
All comments (0)
No comment.

Items in the repository are protected by copyright, with all rights reserved, unless otherwise indicated.