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Research and development of antibiotics: insights from patents and citation network
Zhang, M1; Kong, XJ2; Zheng, J3; Wan, JB2; Wang, YT2; Hu, YJ2; Shao, R1
2016
Source PublicationEXPERT OPINION ON THERAPEUTIC PATENTS
ISSN1354-3776
Volume26Issue:5Pages:617-627
Abstract

Introduction: Bacterial resistance to antibiotics develops at an alarming rate and leads to the increasing morbidity and health-care costs in recent years. However, the global research and development (R&D) of antibiotics has fallen behind the emergence and spread of bacterial resistance and the world is heading towards a ‘post-antibiotic era’. In this context, systematic understanding of the technology landscape and evolving process of antibiotic R&D may help to provide insights for discovering future antibiotics more rationally.

Areas covered: Patents and patent citations are broadly believed to be powerful tools in representing the technology advances and capturing technology flows. In all, 707 U.S. patents related to antibiotic R&D are collected and analyzed. Furthermore, patent citations are visualized by a network-based approach, while the inter-relationship between patented technologies on antibiotics is further revealed.

Expert opinion: The current dry pipeline of antibiotic development requires substantial awareness and political support. It is essential to build an attractive and supportive environment for investment. Thus, a new antibiotic business model is needed to chase the balance between the market-oriented investment and public health goals. Additionally, drug development targeting Gram-negative bacteria, especially resistant Gram-negative bacteria, demands attentions from stakeholders because of their unmet medical needs.

KeywordAntibiotics Patent Patent Citation Network Technology Flows Technology Landscape
DOIhttps://doi.org/10.1517/13543776.2016.1167877
Indexed BySCI
Language英语
WOS Research AreaPharmacology & Pharmacy
WOS SubjectChemistry, Medicinal ; Pharmacology & Pharmacy
WOS IDWOS:000374900000007
Fulltext Access
Citation statistics
Cited Times [WOS]:2   [WOS Record]     [Related Records in WOS]
Document TypeJournal article
CollectionInstitute of Chinese Medical Sciences
Faculty of Health Sciences
THE STATE KEY LABORATORY OF QUALITY RESEARCH IN CHINESE MEDICINE (UNIVERSITY OF MACAU)
Corresponding AuthorHu, YJ; Shao, R
Affiliation1.China Pharmaceut Univ, Sch Int Pharmaceut Business, Nanjing 211198, Jiangsu, Peoples R China
2.Univ Macau, State Key Lab Qual Res Chinese Med, Inst Chinese Med Sci, Taipa 999078, Macao, Peoples R China
3.Univ Macau, Fac Hlth Sci, Taipa 999078, Macao, Peoples R China
Corresponding Author AffilicationUniversity of Macau
Recommended Citation
GB/T 7714
Zhang, M,Kong, XJ,Zheng, J,et al. Research and development of antibiotics: insights from patents and citation network[J]. EXPERT OPINION ON THERAPEUTIC PATENTS,2016,26(5):617-627.
APA Zhang, M.,Kong, XJ.,Zheng, J.,Wan, JB.,Wang, YT.,...&Shao, R.(2016).Research and development of antibiotics: insights from patents and citation network.EXPERT OPINION ON THERAPEUTIC PATENTS,26(5),617-627.
MLA Zhang, M,et al."Research and development of antibiotics: insights from patents and citation network".EXPERT OPINION ON THERAPEUTIC PATENTS 26.5(2016):617-627.
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