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Pharmacological Effects and Mechanisms of Chinese Medicines Modulating NLRP3 Inflammasomes in Ischemic Cardio/Cerebral Vascular Disease
Yueying Li1,2; Yuntao Liu1,3; Xia Yan1,3; Qing Liu1,2,4; Yong-Hua Zhao2; Da-Wei Wang1,3
2018-11-10
Source PublicationAmerican Journal of Chinese Medicine
ISSN0192-415X
Volume46Issue:8Pages:1727-1741
Abstract

Cardio/cerebral-vascular diseases seriously threaten human health and are the leading cause of death. As such, there is great interest in identifying a potential mechanism that controls the development process of cardio/cerebral vascular diseases. Present studies demonstrate that inflammasomes play an important role in the process of ischemic cardio/cerebral vascular diseases (ICCVDs). Among the pathological process of ICCVDs, inflammasomes activated the sterile inflammatory response that accelerated the development of diseases and aggravated the acute lesion of tissue. As the most thoroughly studied inflammasome, the NLRP3 inflammasome has been proven to be a potential therapeutic target for ICCVDs. In this review, we summarized the mechanisms of Chinese herbal medicine which can affect ICCVDs via the regulation of the NLRP3 inflammasome. Our study discovers that active compounds of Chinese medicines have a negative effect on NLRP3 in different ICCVDs models. Astragaloside IV may influence the receptor of the cell membrane to inhibit NLRP3 activation. Resveratrol, colchicinesis, salvianolic acid B, chrysophanol and sulforaphane may directly damage the formation of NLRP3 by inhibiting ASC or Caspase-1. Most of the active natural compounds can negatively regulate the downstream products of NLRP3 inflammasome such as IL-18 and IL1ββ. In addition, Chinese medicines such as sinomenine, ruscogenin, resveratrol, arctigenin and cepharanthineas may downregulate NLRP3 inflammasome by inducing autophagy activation. Due to the advantages of multi-target effects, Chinese herbal medicine can be treated as a splendid therapy for ICCVDs by inhibiting NLRP3 inflammasome.

KeywordNlrp3 Inflammasome Cardiovascular Diseases Cerebrovascular Diseases Chinese Medicine Review
DOIhttps://doi.org/10.1142/S0192415X18500878
Indexed By其他
Language英语
WOS Research AreaIntegrative & Complementary Medicine ; General & Internal Medicine
WOS SubjectIntegrative & Complementary Medicine ; Medicine, General & Internal
WOS IDWOS:000455230200003
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Cited Times [WOS]:1   [WOS Record]     [Related Records in WOS]
Document TypeJournal article
CollectionInstitute of Chinese Medical Sciences
Corresponding AuthorYong-Hua Zhao; Da-Wei Wang
Affiliation1.The Second Clinical School of Medicine Guangzhou University of Chinese Medicine Guangzhou 510405, P. R. China
2.State Key Laboratory of Quality Research in Chinese Medicine Faculty of Chinese Medicine Macau University of Science and Technology Macao 999078, Macao SAR of P. R. China
3.Guangdong Provincial Key Laboratory of Research on Emergency in TCM Guangdong Provincial Hospital of Chinese Medicine Guangdong 510405, P. R. China
4.Department of Immunology, School of Basic Medical Sciences Fudan University, Shanghai 200032, P. R. China
Recommended Citation
GB/T 7714
Yueying Li,Yuntao Liu,Xia Yan,et al. Pharmacological Effects and Mechanisms of Chinese Medicines Modulating NLRP3 Inflammasomes in Ischemic Cardio/Cerebral Vascular Disease[J]. American Journal of Chinese Medicine,2018,46(8):1727-1741.
APA Yueying Li,Yuntao Liu,Xia Yan,Qing Liu,Yong-Hua Zhao,&Da-Wei Wang.(2018).Pharmacological Effects and Mechanisms of Chinese Medicines Modulating NLRP3 Inflammasomes in Ischemic Cardio/Cerebral Vascular Disease.American Journal of Chinese Medicine,46(8),1727-1741.
MLA Yueying Li,et al."Pharmacological Effects and Mechanisms of Chinese Medicines Modulating NLRP3 Inflammasomes in Ischemic Cardio/Cerebral Vascular Disease".American Journal of Chinese Medicine 46.8(2018):1727-1741.
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