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Tetrahydrocurcumin, a major metabolite of curcumin, ameliorates allergic airway inflammation by attenuating Th2 response and suppressing the IL-4R alpha-Jak1-STAT6 and Jagged1/Jagged2-Notch1/Notch2 pathways in asthmatic mice
Chen, Bin Lin1,2; Chen, Yan Qiu3; Ma, Bai Hui1,2; Yu, Si Fei4; Li, Li Yue5,6; Zeng, Qing Xiang3; Zhou, Yu Tao5,6; Wu, Yin Fan1,2; Liu, Wen Long3; Wan, Jian Bo7; Yang, Yan1,2; Li, Chun Wei5,6
2018-11
Source PublicationCLINICAL AND EXPERIMENTAL ALLERGY
ISSN0954-7894
Volume48Issue:11Pages:1494-1508
AbstractBackground: Curcumin (Cur), derived from Curcuma species, exhibits anti-inflammatory, antioxidant, and anticancer effects. Although Cur has some beneficial effects on asthma, its clinical application is limited by its low bioavailability. Tetrahydrocurcumin (THC), the major active metabolite of Cur, has multiple biological functions, similarly to Cur, and importantly, it showed enhanced bioavailability in tissues and plasma. However, the effect of THC on asthma has not been reported.
Keywordairway inflammation asthma dietary factor tetrahydrocurcumin Th2 response
DOI10.1111/cea.13258
URLView the original
Indexed BySCI
Language英语
WOS Research AreaAllergy ; Immunology
WOS SubjectAllergy ; Immunology
WOS IDWOS:000449542500013
PublisherWILEY
Fulltext Access
Citation statistics
Cited Times [WOS]:2   [WOS Record]     [Related Records in WOS]
Document TypeJournal article
CollectionUniversity of Macau
Affiliation1.Sun Yat Sen Univ, Sch Publ Hlth Shenzhen, Guangzhou, Guangdong, Peoples R China;
2.Sun Yat Sen Univ, Sch Publ Hlth, Guangdong Prov Key Lab Food Nutr & Hlth, Guangzhou Campus, Guangzhou, Guangdong, Peoples R China;
3.Guangzhou Women & Children Med Ctr, Dept Otolaryngol, Guangzhou, Guangdong, Peoples R China;
4.Sun Yat Sen Univ, Zhongshan Sch Med, Inst Immunol, Guangzhou, Guangdong, Peoples R China;
5.Sun Yat Sen Univ, Affiliated Hosp 1, Dept Otolaryngol, Guangzhou, Guangdong, Peoples R China;
6.Sun Yat Sen Univ, Affiliated Hosp 1, Guangzhou Key Lab Otorhinolaryngol, Guangzhou, Guangdong, Peoples R China;
7.Univ Macau, Inst Chinese Med Sci, State Key Lab Qual Res Chinese Med, Macau, Peoples R China
Recommended Citation
GB/T 7714
Chen, Bin Lin,Chen, Yan Qiu,Ma, Bai Hui,et al. Tetrahydrocurcumin, a major metabolite of curcumin, ameliorates allergic airway inflammation by attenuating Th2 response and suppressing the IL-4R alpha-Jak1-STAT6 and Jagged1/Jagged2-Notch1/Notch2 pathways in asthmatic mice[J]. CLINICAL AND EXPERIMENTAL ALLERGY,2018,48(11):1494-1508.
APA Chen, Bin Lin.,Chen, Yan Qiu.,Ma, Bai Hui.,Yu, Si Fei.,Li, Li Yue.,...&Li, Chun Wei.(2018).Tetrahydrocurcumin, a major metabolite of curcumin, ameliorates allergic airway inflammation by attenuating Th2 response and suppressing the IL-4R alpha-Jak1-STAT6 and Jagged1/Jagged2-Notch1/Notch2 pathways in asthmatic mice.CLINICAL AND EXPERIMENTAL ALLERGY,48(11),1494-1508.
MLA Chen, Bin Lin,et al."Tetrahydrocurcumin, a major metabolite of curcumin, ameliorates allergic airway inflammation by attenuating Th2 response and suppressing the IL-4R alpha-Jak1-STAT6 and Jagged1/Jagged2-Notch1/Notch2 pathways in asthmatic mice".CLINICAL AND EXPERIMENTAL ALLERGY 48.11(2018):1494-1508.
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