UM  > 健康科學學院
Effect of adjunctive ranitidine for antipsychotic-induced weight gain: A systematic review of randomized placebo-controlled trials
Gu, Xiao-Jing1; Chen, Rui2; Sun, Chen-Hui3; Zheng, Wei4; Yang, Xin-Hu4; Wang, Shi-Bin5; Ungvari, Gabor S.6,7; Ng, Chee H.8; Golenkov, Andrei9; Lok, Grace K. I.5; Li, Lu5; Chow, Ines H. I.5; Wang, Fei5; Xiang, Yu-Tao5
2018-01
Source PublicationJOURNAL OF INTERNATIONAL MEDICAL RESEARCH
ISSN0300-0605
Volume46Issue:1Pages:22-32
Abstract

This study was a meta-analysis of randomized controlled trials (RCTs) of ranitidine as an adjunct for antipsychotic-induced weight gain in patients with schizophrenia. RCTs reporting weight gain or metabolic side effects in patients with schizophrenia were included. Case reports/series, non-randomized or observational studies, reviews, and meta-analyses were excluded. The primary outcome measures were body mass index (BMI) (kg/m(2)) and body weight (kg). Four RCTs with five study arms were identified and analyzed. Compared with the control group, adjunctive ranitidine was associated with marginally significant reductions in BMI and body weight. After removing an outlier study for BMI, the effect of ranitidine remained significant. Adjunctive ranitidine outperformed the placebo in the negative symptom score of the Positive and Negative Syndrome Scale. Although ranitidine was associated with less frequent drowsiness, other adverse events were similar between the two groups. Adjunctive ranitidine appears to be an effective and safe option for reducing antipsychotic-induced weight gain and improving negative symptoms in patients with schizophrenia. Larger RCTs are warranted to confirm these findings.

KeywordSchizophrenia Ranitidine Weight Gain Negative Symptom Meta-analysis Antipsychotics
DOIhttp://doi.org/10.1177/0300060517716783
URLView the original
Indexed BySCI
Language英语
WOS Research AreaResearch & Experimental Medicine ; Pharmacology & Pharmacy
WOS SubjectMedicine, Research & Experimental ; Pharmacology & Pharmacy
WOS IDWOS:000419863700003
PublisherSAGE PUBLICATIONS LTD
The Source to ArticleWOS
Fulltext Access
Citation statistics
Cited Times [WOS]:4   [WOS Record]     [Related Records in WOS]
Document TypeJournal article
CollectionFaculty of Health Sciences
Corresponding AuthorXiang, Yu-Tao
Affiliation1.The Second Affiliated Hospital of Xinxiang Medical University Henan Mental Hospital, Henan, China
2.Beijing Key Laboratory of Mental Disorders, Beijing Anding Hospital, Capital Medical University, Beijing, China
3.Qingdao Mental Health Center, Shandong, China
4.The Affiliated Brain Hospital of Guangzhou Medical University (Guangzhou Huiai Hospital), Guangzhou, China
5.Unit of Psychiatry, Faculty of Health Sciences, University of Macau, Macao SAR, China
6.The University of Notre Dame Australia/Marian Centre, Perth, Australia
7.School of Psychiatry & Clinical Neurosciences, University of Western Australia, Perth, Australia
8.Department of Psychiatry, University of Melbourne, Melbourne, Victoria, Australia
9.Department of Psychiatry and Medical Psychology, Chuvash State University, Cheboksary, Russia
Corresponding Author AffilicationFaculty of Health Sciences
Recommended Citation
GB/T 7714
Gu, Xiao-Jing,Chen, Rui,Sun, Chen-Hui,et al. Effect of adjunctive ranitidine for antipsychotic-induced weight gain: A systematic review of randomized placebo-controlled trials[J]. JOURNAL OF INTERNATIONAL MEDICAL RESEARCH,2018,46(1):22-32.
APA Gu, Xiao-Jing.,Chen, Rui.,Sun, Chen-Hui.,Zheng, Wei.,Yang, Xin-Hu.,...&Xiang, Yu-Tao.(2018).Effect of adjunctive ranitidine for antipsychotic-induced weight gain: A systematic review of randomized placebo-controlled trials.JOURNAL OF INTERNATIONAL MEDICAL RESEARCH,46(1),22-32.
MLA Gu, Xiao-Jing,et al."Effect of adjunctive ranitidine for antipsychotic-induced weight gain: A systematic review of randomized placebo-controlled trials".JOURNAL OF INTERNATIONAL MEDICAL RESEARCH 46.1(2018):22-32.
Related Services
Recommend this item
Bookmark
Usage statistics
Export to Endnote
Google Scholar
Similar articles in Google Scholar
[Gu, Xiao-Jing]'s Articles
[Chen, Rui]'s Articles
[Sun, Chen-Hui]'s Articles
Baidu academic
Similar articles in Baidu academic
[Gu, Xiao-Jing]'s Articles
[Chen, Rui]'s Articles
[Sun, Chen-Hui]'s Articles
Bing Scholar
Similar articles in Bing Scholar
[Gu, Xiao-Jing]'s Articles
[Chen, Rui]'s Articles
[Sun, Chen-Hui]'s Articles
Terms of Use
No data!
Social Bookmark/Share
All comments (0)
No comment.
 

Items in the repository are protected by copyright, with all rights reserved, unless otherwise indicated.