UM
A Role for MK2 in Enhancing Neutrophil-Derived ROS Production and Aggravating Liver schemia/Reperfusion Injury
Sun, Lei1; Wu, Qiong2; Nie, Yunjuan1; Cheng, Ni3; Wang, Rui2; Wang, Gang4; Zhang, Dan2; He, Huiqiong1; Ye, Richard D.1,5; Qian, Fang1,2,4
2018-11-13
Source PublicationFRONTIERS IN IMMUNOLOGY
ISSN1664-3224
Volume9
AbstractIncreased inflammatory responses and enhanced reactive oxygen species contribute to hepatic ischemia/reperfusion (I/R) injury, however the modulatory mechanisms haven't been completely unveiled. Here, we report that genetic deficiency of MAPK-activated protein kinase 2 (MK2) protected against hepatic I/R injury and decreased hepatic neutrophil accumulation in MK2(-/-) mice. Depletion of neutrophil attenuated hepatic I/R injury in wide type mice. In response to C5a stimulation, MK2(-/-) neutrophils generated less superoxide in which both NADPH oxidase activation and p47Ph" phosphorylation were decreased. Furthermore, Ser329 of p47(ph)(ox) was identified for enhancement of superoxide production. The Ser329 phosphorylation was reduced in MK2(-/-)neutrophils. To determine whether MK2 modulates hepatic I/R injury via activating neutrophils, we generated myeloid-specific MK2 deletion mice (NAK2(Lyz2-Ko)) and liver I/R injury was reduced in NAK2(Lyz2-Ko) mice. Our results indicate that MK2 augments hepatic I/R injury and induces ROS production with increased p47(ph)(ox) phosphorylation and MK2 is a potential drug target for treating hepatic I/R injury.
KeywordMK2 ROS p47(phox) neutrophils hepatic ischemia/reperfusion injury
DOI10.3389/fimmu.2018.02610
URLView the original
Indexed BySCI
Language英语
WOS Research AreaImmunology
WOS SubjectImmunology
WOS IDWOS:000450023700004
PublisherFRONTIERS MEDIA SA
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Cited Times [WOS]:1   [WOS Record]     [Related Records in WOS]
Document TypeJournal article
CollectionUniversity of Macau
Affiliation1.Shanghai Jiao Tong Univ, Sch Pharm, Minist Educ, Engn Res Ctr Cell & Therapeut Antibody, Shanghai, Peoples R China;
2.Bengbu Med Coll, Anhui Prov Key Lab Translat Canc Res, Bengbu, Peoples R China;
3.Univ Illinois, Coll Med, Dept Pharmacol, Chicago, IL USA;
4.Xuzhou Med Univ, Canc Inst, Jiangsu Ctr Collaborat & Innovat Canc Biotherapy, Xuzhou, Jiangsu, Peoples R China;
5.Univ Macau, Inst Chinese Med Sci, Macau, Peoples R China
Recommended Citation
GB/T 7714
Sun, Lei,Wu, Qiong,Nie, Yunjuan,et al. A Role for MK2 in Enhancing Neutrophil-Derived ROS Production and Aggravating Liver schemia/Reperfusion Injury[J]. FRONTIERS IN IMMUNOLOGY,2018,9.
APA Sun, Lei.,Wu, Qiong.,Nie, Yunjuan.,Cheng, Ni.,Wang, Rui.,...&Qian, Fang.(2018).A Role for MK2 in Enhancing Neutrophil-Derived ROS Production and Aggravating Liver schemia/Reperfusion Injury.FRONTIERS IN IMMUNOLOGY,9.
MLA Sun, Lei,et al."A Role for MK2 in Enhancing Neutrophil-Derived ROS Production and Aggravating Liver schemia/Reperfusion Injury".FRONTIERS IN IMMUNOLOGY 9(2018).
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