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Protein-modified conjugated polymer nanoparticles with strong near-infrared absorption: a novel nanoplatform to design multifunctional nanoprobes for dual-modal photoacoustic and fluorescence imaging
Duyang Gao1; Pengfei Zhang2; Yubin Liu1; Zonghai Sheng3; Huajie Chen4; Zhen Yuan1
2018-11-14
Source PublicationNANOSCALE
ISSN2040-3364
Volume10Issue:42Pages:19742-19748
Abstract

Engineering conjugated polymer nanoparticles (CPNs) with an easily-modified surface is essential to construct multifunctional nanoprobes as contrast agents for dual-modal photoacoustic (PA) and fluorescence imaging, which can take advantages of the complementary information from a single modality. In this study, an abundant protein with plenty of functional groups was introduced for the first time to produce easily-modified CPNs, leading to a robust nanoplatform to engineer PA-based multifunctional nanoprobes due to their strong optical absorption in the near-infrared region. Meanwhile, the bovine serum albumin (BSA)-modified CPNs were further engineered by introducing gold clusters in situ, which can serve as fluorescent nanoprobes for dual-modal molecular imaging. In particular, the developed nanoplatform exhibited superior stability and excellent biocompatibility, making it an ideal candidate for various cancer-theranostics applications. More importantly, our imaging results demonstrated that the BSA-modified CPNs were excellent candidates to design PA-based contrast agents for multimodal imaging using the function of the protein. In addition, other functional blocks can also be added to the nanoplatform based on its easily-modified surface, making it a general method for the construction of multifunctional nanoprobes for disease theranostics.

DOI10.1039/c8nr06197a
URLView the original
Indexed BySCI
Language英语
WOS Research AreaChemistry ; Science & Technology - Other Topics ; Materials Science ; Physics
WOS SubjectChemistry, Multidisciplinary ; Nanoscience & Nanotechnology ; Materials Science, Multidisciplinary ; Physics, Applied
WOS IDWOS:000449699400007
PublisherROYAL SOC CHEMISTRY
Fulltext Access
Citation statistics
Cited Times [WOS]:7   [WOS Record]     [Related Records in WOS]
Document TypeJournal article
CollectionFaculty of Health Sciences
INSTITUTE OF COLLABORATIVE INNOVATION
Corresponding AuthorHuajie Chen; Zhen Yuan
Affiliation1.Bioimaging Core, Faculty of Health Sciences, University of Macau, Macao, China
2.Guangdong Key Laboratory of Nanomedicine, Shenzhen Engineering Laboratory of Nanomedicine and Nanoformulations, CAS Key Laboratory of Health Informatics, Institute of Biomedicine and Biotechnology, Shenzhen Institutes of Advanced Technology, Chinese Academ
3.Paul C. Lauterbur Research Center for Biomedical Imaging, Institute of Biomedical and Health Engineering, Shenzhen Institutes of Advanced Technology, Chinese Academy of Sciences, Shenzhen, P. R. China
4.Key Laboratory of Advanced Functional Polymeric Materials of College of Hunan Province, and Key Laboratory of Environmentally Friendly Chemistry and Applications of Ministry of Education, College of Chemistry, Xiangtan University, Xiangtan 411105
First Author AffilicationFaculty of Health Sciences
Corresponding Author AffilicationFaculty of Health Sciences
Recommended Citation
GB/T 7714
Duyang Gao,Pengfei Zhang,Yubin Liu,et al. Protein-modified conjugated polymer nanoparticles with strong near-infrared absorption: a novel nanoplatform to design multifunctional nanoprobes for dual-modal photoacoustic and fluorescence imaging[J]. NANOSCALE,2018,10(42):19742-19748.
APA Duyang Gao,Pengfei Zhang,Yubin Liu,Zonghai Sheng,Huajie Chen,&Zhen Yuan.(2018).Protein-modified conjugated polymer nanoparticles with strong near-infrared absorption: a novel nanoplatform to design multifunctional nanoprobes for dual-modal photoacoustic and fluorescence imaging.NANOSCALE,10(42),19742-19748.
MLA Duyang Gao,et al."Protein-modified conjugated polymer nanoparticles with strong near-infrared absorption: a novel nanoplatform to design multifunctional nanoprobes for dual-modal photoacoustic and fluorescence imaging".NANOSCALE 10.42(2018):19742-19748.
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