UM
Protein-modified conjugated polymer nanoparticles with strong near-infrared absorption: a novel nanoplatform to design multifunctional nanoprobes for dual-modal photoacoustic and fluorescence imaging
Gao, Duyang1; Zhang, Pengfei2; Liu, Yubin1; Sheng, Zonghai3; Chen, Huajie4,5; Yuan, Zhen1
2018-11-14
Source PublicationNANOSCALE
ISSN2040-3364
Volume10Issue:42Pages:19742-19748
AbstractEngineering conjugated polymer nanoparticles (CPNs) with an easily-modified surface is essential to construct multifunctional nanoprobes as contrast agents for dual-modal photoacoustic (PA) and fluorescence imaging, which can take advantages of the complementary information from a single modality. In this study, an abundant protein with plenty of functional groups was introduced for the first time to produce easily-modified CPNs, leading to a robust nanoplatform to engineer PA-based multifunctional nanoprobes due to their strong optical absorption in the near-infrared region. Meanwhile, the bovine serum albumin (BSA)-modified CPNs were further engineered by introducing gold clusters in situ, which can serve as fluorescent nanoprobes for dual-modal molecular imaging. In particular, the developed nanoplatform exhibited superior stability and excellent biocompatibility, making it an ideal candidate for various cancer-theranostics applications. More importantly, our imaging results demonstrated that the BSA-modified CPNs were excellent candidates to design PA-based contrast agents for multimodal imaging using the function of the protein. In addition, other functional blocks can also be added to the nanoplatform based on its easily-modified surface, making it a general method for the construction of multifunctional nanoprobes for disease theranostics.
DOI10.1039/c8nr06197a
URLView the original
Indexed BySCI
Language英语
WOS Research AreaChemistry ; Science & Technology - Other Topics ; Materials Science ; Physics
WOS SubjectChemistry, Multidisciplinary ; Nanoscience & Nanotechnology ; Materials Science, Multidisciplinary ; Physics, Applied
WOS IDWOS:000449699400007
PublisherROYAL SOC CHEMISTRY
Fulltext Access
Citation statistics
Cited Times [WOS]:2   [WOS Record]     [Related Records in WOS]
Document TypeJournal article
CollectionUniversity of Macau
Affiliation1.Univ Macau, Fac Hlth Sci, Bioimaging Core, Macau, Peoples R China;
2.Chinese Acad Sci, Shenzhen Inst Adv Technol, Inst Biomed & Biotechnol,Shenzhen Engn Lab Nanome, Guangdong Key Lab Nanomed,CAS Key Lab Hlth Inform, Shenzhen 518055, Peoples R China;
3.Chinese Acad Sci, Shenzhen Inst Adv Technol, Inst Biomed & Hlth Engn, Paul C Lauterbur Res Ctr Biomed Imaging, Shenzhen, Peoples R China;
4.Xiangtan Univ, Coll Chem, Coll Hunan Prov, Key Lab Adv Funct Polymer Mat,Minist Educ, Xiangtan 411105, Peoples R China;
5.Xiangtan Univ, Coll Chem, Key Lab Environm Friendly Chem & Applicat, Minist Educ, Xiangtan 411105, Peoples R China
First Author AffilicationUniversity of Macau
Recommended Citation
GB/T 7714
Gao, Duyang,Zhang, Pengfei,Liu, Yubin,et al. Protein-modified conjugated polymer nanoparticles with strong near-infrared absorption: a novel nanoplatform to design multifunctional nanoprobes for dual-modal photoacoustic and fluorescence imaging[J]. NANOSCALE,2018,10(42):19742-19748.
APA Gao, Duyang,Zhang, Pengfei,Liu, Yubin,Sheng, Zonghai,Chen, Huajie,&Yuan, Zhen.(2018).Protein-modified conjugated polymer nanoparticles with strong near-infrared absorption: a novel nanoplatform to design multifunctional nanoprobes for dual-modal photoacoustic and fluorescence imaging.NANOSCALE,10(42),19742-19748.
MLA Gao, Duyang,et al."Protein-modified conjugated polymer nanoparticles with strong near-infrared absorption: a novel nanoplatform to design multifunctional nanoprobes for dual-modal photoacoustic and fluorescence imaging".NANOSCALE 10.42(2018):19742-19748.
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