Fungal Component Coating Enhances Titanium Implant-Bone Integration
Shi, Yuchen1; Wang, Lintao1,2; Niu, Yiming1; Yu, Na3,4; Xing, Panfei1; Dong, Lei2; Wang, Chunming1
AbstractBioactive coating on bone and dental implants is widely used to increase their integration with the host tissue, with millions of implantations performed globally each year. Numerous coating strategies focus on creating a cell-adhesive surface by employing bone matrix components, but insufficient integration and its associated complications remain a substantial clinical challenge. Designing an implant coating to more comprehensively promote healing while appropriately modulating host immune response is still an unfulfilled promise. This study reports the development of a polysaccharide coating that can improve osseointegration by targeting and regulating inflammatory activity at the implant surface. Zymosan-a fungal component-is screened and covalently grafted onto titanium (Ti) substrates. The zymosan coating specifically stimulates macrophages through toll-like receptors into a proregenerative phenotype, which produces abundant osteogenic/angiogenic cytokines to enhance osteogenic activities locally. Further assessment in a rat femur condyle defect indicates that zymosan coated at a medium dose (0.1 mu g mm(-2)) remarkably increases the integration of Ti column with bone tissue, causing no abnormality to the host. This is the first demonstration that modulating inflammation with an immunoactive coating material can promote bone-implant integration, which may inspire new strategies for the design of bone and dental implants.
Keywordimplant coating inflammation macrophages osseointegration polysaccharides
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Indexed BySCI
WOS Research AreaChemistry ; Science & Technology - Other Topics ; Materials Science ; Physics
WOS SubjectChemistry, Multidisciplinary ; Chemistry, Physical ; Nanoscience & Nanotechnology ; Materials Science, Multidisciplinary ; Physics, Applied ; Physics, Condensed Matter
WOS IDWOS:000449887300008
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Cited Times [WOS]:3   [WOS Record]     [Related Records in WOS]
Document TypeJournal article
CollectionUniversity of Macau
Affiliation1.Univ Macau, Inst Chinese Med Sci, State Key Lab Qual Res Chinese Med, Macau, Peoples R China;
2.Nanjing Univ, State Key Lab Pharmaceut Biotechnol, Nanjing 210093, Jiangsu, Peoples R China;
3.Natl Dent Ctr Singapore, 5 Second Hosp Ave, Singapore 168938, Singapore;
4.Duke NUS Med Sch, 8 Coll Rd, Singapore 169857, Singapore
First Author AffilicationUniversity of Macau
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GB/T 7714
Shi, Yuchen,Wang, Lintao,Niu, Yiming,et al. Fungal Component Coating Enhances Titanium Implant-Bone Integration[J]. ADVANCED FUNCTIONAL MATERIALS,2018,28(46).
APA Shi, Yuchen.,Wang, Lintao.,Niu, Yiming.,Yu, Na.,Xing, Panfei.,...&Wang, Chunming.(2018).Fungal Component Coating Enhances Titanium Implant-Bone Integration.ADVANCED FUNCTIONAL MATERIALS,28(46).
MLA Shi, Yuchen,et al."Fungal Component Coating Enhances Titanium Implant-Bone Integration".ADVANCED FUNCTIONAL MATERIALS 28.46(2018).
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