UM
Novel lncRNA LINC00844 Regulates Prostate Cancer Cell Migration and Invasion through AR Signaling
Lingadahalli, Shreyas1; Jadhao, Sudhir1; Sung, Ying Ying2; Chen, Mi1; Hu, Lingling1; Chen, Xin1,3; Cheung, Edwin1
2018-12
Source PublicationMOLECULAR CANCER RESEARCH
ISSN1541-7786
Volume16Issue:12Pages:1865-1878
AbstractThe human genome is mostly transcribed, yielding a rich repository of noncoding transcripts that are involved in a myriad of biological processes including cancer. However, how many noncoding transcripts such as long noncoding RNAs (lncRNA) function in cancer is still unclear. This study identified a novel set of clinically relevant androgen-regulated lncRNAs in prostate cancer. Among this group, LINC00844 was demonstrated to be a direct androgen-regulated target that is actively transcribed in androgen receptor (AR)-dependent prostate cancer cells. The expression of LINC00844 is higher in normal prostate compared with malignant and metastatic prostate cancer clinical specimens, and patients with low expression had a poor prognosis and significantly increased biochemical recurrence, suggesting LINC00844 functions in suppressing tumor progression and metastasis. Indeed, in vitro loss-of-function studies revealed that LINC00844 prevents prostate cancer cell migration and invasion. Moreover, findings from gene expression profiling analysis indicated that LINC00844 functions in trans, affecting global androgen-regulated gene transcription. Mechanistic evidence reveals that LINC00844 is important in facilitating AR binding to the chromatin. Finally, LINC00844 mediates its phenotypic effects in part by activating the expression of NDRG1, a crucial cancer metastasis suppressor. Collectively, LINC00844 is a novel coregulator of AR that plays a central role in the androgen transcriptional network and the development and progression of prostate cancer.
DOI10.1158/1541-7786.MCR-18-0087
URLView the original
Indexed BySCI
Language英语
WOS Research AreaOncology ; Cell Biology
WOS SubjectOncology ; Cell Biology
WOS IDWOS:000452375800006
PublisherAMER ASSOC CANCER RESEARCH
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Cited Times [WOS]:9   [WOS Record]     [Related Records in WOS]
Document TypeJournal article
CollectionUniversity of Macau
Affiliation1.Univ Macau, Fac Hlth Sci, Canc Ctr, Taipa, Macau, Peoples R China;
2.Genome Inst Singapore, Singapore, Singapore;
3.Guangdong Univ Technol, Sch Automat, Guangzhou, Guangdong, Peoples R China
First Author AffilicationUniversity of Macau
Recommended Citation
GB/T 7714
Lingadahalli, Shreyas,Jadhao, Sudhir,Sung, Ying Ying,et al. Novel lncRNA LINC00844 Regulates Prostate Cancer Cell Migration and Invasion through AR Signaling[J]. MOLECULAR CANCER RESEARCH,2018,16(12):1865-1878.
APA Lingadahalli, Shreyas.,Jadhao, Sudhir.,Sung, Ying Ying.,Chen, Mi.,Hu, Lingling.,...&Cheung, Edwin.(2018).Novel lncRNA LINC00844 Regulates Prostate Cancer Cell Migration and Invasion through AR Signaling.MOLECULAR CANCER RESEARCH,16(12),1865-1878.
MLA Lingadahalli, Shreyas,et al."Novel lncRNA LINC00844 Regulates Prostate Cancer Cell Migration and Invasion through AR Signaling".MOLECULAR CANCER RESEARCH 16.12(2018):1865-1878.
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