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MnSOD mediates shear stress-promoted tumor cell migration and adhesion
Ma, Shijun1; Fu, Afu1; Lim, Sierin1; Chiew, Geraldine Giap Ying1; Luo, Kathy Qian2
2018-12
Source PublicationFREE RADICAL BIOLOGY AND MEDICINE
ISSN0891-5849
Volume129Pages:46-58
AbstractCirculation of cancer cells in the bloodstream is a vital step for distant metastasis, during which cancer cells are exposed to hemodynamic shear stress (SS). The actions of SS on tumor cells are complicated and not fully understood. We previously reported that fluidic SS was able to promote migration of breast cancer cells by elevating the cellular ROS level. In this study, we further investigated the mechanisms regulating SS-promoted cell migration and identified the role of MnSOD in the related pathway. We found that SS could enhance tumor cell adhesion to extracellular matrix and endothelial monolayer, and MnSOD also regulated this process. Briefly, SS stimulates the generation of mitochondrial superoxide in tumor cells. MnSOD then converts superoxide into hydrogen peroxide, which activates ERK1/2 to promote tumor cell migration and activates FAK to promote tumor cell adhesion. Combining our previous and present studies, we present experimental evidence on the pro-metastatic effects of hemodynamic SS and reveal the underlying mechanism. Our findings provide new insights into the nature of cancer metastasis and the understanding of tumor cell responses to external stresses and have valuable implications for cancer therapy development.
KeywordShear stress Tumor cell adhesion Tumor cell migration Reactive oxygen species MnSOD FAK
DOI10.1016/j.freeradbiomed.2018.09.004
URLView the original
Indexed BySCI
Language英语
WOS Research AreaBiochemistry & Molecular Biology ; Endocrinology & Metabolism
WOS SubjectBiochemistry & Molecular Biology ; Endocrinology & Metabolism
WOS IDWOS:000450298400004
PublisherELSEVIER SCIENCE INC
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Cited Times [WOS]:2   [WOS Record]     [Related Records in WOS]
Document TypeJournal article
CollectionUniversity of Macau
Affiliation1.Nanyang Technol Univ, Sch Chem & Biomed Engn, Singapore, Singapore;
2.Univ Macau, Fac Hlth Sci, Taipa, Macau, Peoples R China
Recommended Citation
GB/T 7714
Ma, Shijun,Fu, Afu,Lim, Sierin,et al. MnSOD mediates shear stress-promoted tumor cell migration and adhesion[J]. FREE RADICAL BIOLOGY AND MEDICINE,2018,129:46-58.
APA Ma, Shijun,Fu, Afu,Lim, Sierin,Chiew, Geraldine Giap Ying,&Luo, Kathy Qian.(2018).MnSOD mediates shear stress-promoted tumor cell migration and adhesion.FREE RADICAL BIOLOGY AND MEDICINE,129,46-58.
MLA Ma, Shijun,et al."MnSOD mediates shear stress-promoted tumor cell migration and adhesion".FREE RADICAL BIOLOGY AND MEDICINE 129(2018):46-58.
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