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Fighting Liver Fibrosis with Naturally Occurring Antioxidants
Lin, Ligen; Zhou, Fayang; Shen, Shengnan; Zhang, Tian
Source PublicationPLANTA MEDICA

Liver fibrosis is a wound-healing response characterized by the accumulation of extracellular matrix following various liver injuries, which results in the deformation of the normal liver architecture and the development of liver cirrhosis and even hepatocellular carcinoma. Numerous in vitro and in vivo studies indicated that oxidative stress mediates the initiation and progression of liver fibrosis. Overaccumulation of reactive oxygen species disrupts macromolecules, induces necrosis and apoptosis of hepatocytes, stimulates the production of pro-fibrogenic mediators, and directly activates hepatic stellate cells, thereby resulting in liver damage and initiating liver fibrosis. Ameliorating oxidative stress is a potential therapeutic strategy for the treatment of liver fibrosis. Natural antioxidants have attracted increasing attention in treating liver fibrosis due to their safety and efficacy. In this review, the pathogenesis of liver fibrosis and the role of oxidative stress in liver fibrosis were discussed. Naturally occurring antioxidants that can treat and prevent liver fibrosis were summarized. Advances in clinical trials were also presented. The main purpose of this review is to provide a comprehensive and up-to-date knowledge from the biological importance of oxidative stress in liver fibrosis to representative antioxidants for treating liver fibrosis. Naturally occurring antioxidants show a potential for further investigations as lead compounds in fighting liver fibrosis.

KeywordLiver Fibrosis Antioxidants Oxidative Stress Reactive Oxygen Species Hepatic Stellate Cells Natural Products
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Indexed BySCI
WOS Research AreaPlant Sciences ; Pharmacology & Pharmacy ; Integrative & Complementary Medicine
WOS SubjectPlant Sciences ; Chemistry, Medicinal ; Integrative & Complementary Medicine ; Pharmacology & Pharmacy
WOS IDWOS:000451563500002
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Cited Times [WOS]:4   [WOS Record]     [Related Records in WOS]
Document TypeJournal article
CollectionInstitute of Chinese Medical Sciences
AffiliationUniv Macau, Inst Chinese Med Sci, State Key Lab Qual Res Chinese Med, Taipa, Macau, Peoples R China
First Author AffilicationUniversity of Macau
Recommended Citation
GB/T 7714
Lin, Ligen,Zhou, Fayang,Shen, Shengnan,et al. Fighting Liver Fibrosis with Naturally Occurring Antioxidants[J]. PLANTA MEDICA,2018,84(18):1318-1333.
APA Lin, Ligen,Zhou, Fayang,Shen, Shengnan,&Zhang, Tian.(2018).Fighting Liver Fibrosis with Naturally Occurring Antioxidants.PLANTA MEDICA,84(18),1318-1333.
MLA Lin, Ligen,et al."Fighting Liver Fibrosis with Naturally Occurring Antioxidants".PLANTA MEDICA 84.18(2018):1318-1333.
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