UM  > 中華醫藥研究院
Pharmacological Inhibition of LSD1 for Cancer Treatment
Yang, Guan-Jun1; Lei, Pui-Man1; Wong, Suk-Yu2; Ma, Dik-Lung2; Leung, Chung-Hang1
Source PublicationMOLECULES

Lysine-specific demethylase 1A (LSD1, also named KDM1A) is a demethylase that can remove methyl groups from histones H3K4me1/2 and H3K9me1/2. It is aberrantly expressed in many cancers, where it impedes differentiation and contributes to cancer cell proliferation, cell metastasis and invasiveness, and is associated with inferior prognosis. Pharmacological inhibition of LSD1 has been reported to significantly attenuate tumor progression in vitro and in vivo in a range of solid tumors and acute myeloid leukemia. This review will present the structural aspects of LSD1, its role in carcinogenesis, a comparison of currently available approaches for screening LSD1 inhibitors, a classification of LSD1 inhibitors, and its potential as a drug target in cancer therapy.

KeywordLsd1 Demethylase Histone Breast Cancer Prostate Cancer Acute Myeloid Leukemia Cancer Therapy
URLView the original
Indexed BySCI
WOS Research AreaBiochemistry & Molecular Biology ; Chemistry
WOS SubjectBiochemistry & Molecular Biology ; Chemistry, Multidisciplinary
WOS IDWOS:000454523000144
Fulltext Access
Citation statistics
Cited Times [WOS]:17   [WOS Record]     [Related Records in WOS]
Document TypeJournal article
CollectionInstitute of Chinese Medical Sciences
Affiliation1.Univ Macau, Inst Chinese Med Sci, State Key Lab Qual Res Chinese Med, Macau 999078, Peoples R China;
2.Hong Kong Baptist Univ, Dept Chem, Kowloon Tong, Hong Kong 999077, Peoples R China
First Author AffilicationUniversity of Macau
Recommended Citation
GB/T 7714
Yang, Guan-Jun,Lei, Pui-Man,Wong, Suk-Yu,et al. Pharmacological Inhibition of LSD1 for Cancer Treatment[J]. MOLECULES,2018,23(12).
APA Yang, Guan-Jun,Lei, Pui-Man,Wong, Suk-Yu,Ma, Dik-Lung,&Leung, Chung-Hang.(2018).Pharmacological Inhibition of LSD1 for Cancer Treatment.MOLECULES,23(12).
MLA Yang, Guan-Jun,et al."Pharmacological Inhibition of LSD1 for Cancer Treatment".MOLECULES 23.12(2018).
Files in This Item:
There are no files associated with this item.
Related Services
Recommend this item
Usage statistics
Export to Endnote
Google Scholar
Similar articles in Google Scholar
[Yang, Guan-Jun]'s Articles
[Lei, Pui-Man]'s Articles
[Wong, Suk-Yu]'s Articles
Baidu academic
Similar articles in Baidu academic
[Yang, Guan-Jun]'s Articles
[Lei, Pui-Man]'s Articles
[Wong, Suk-Yu]'s Articles
Bing Scholar
Similar articles in Bing Scholar
[Yang, Guan-Jun]'s Articles
[Lei, Pui-Man]'s Articles
[Wong, Suk-Yu]'s Articles
Terms of Use
No data!
Social Bookmark/Share
All comments (0)
No comment.

Items in the repository are protected by copyright, with all rights reserved, unless otherwise indicated.