UM
Pharmacological Inhibition of LSD1 for Cancer Treatment
Yang, Guan-Jun1; Lei, Pui-Man1; Wong, Suk-Yu2; Ma, Dik-Lung2; Leung, Chung-Hang1
2018-12
Source PublicationMOLECULES
ISSN1420-3049
Volume23Issue:12
AbstractLysine-specific demethylase 1A (LSD1, also named KDM1A) is a demethylase that can remove methyl groups from histones H3K4me1/2 and H3K9me1/2. It is aberrantly expressed in many cancers, where it impedes differentiation and contributes to cancer cell proliferation, cell metastasis and invasiveness, and is associated with inferior prognosis. Pharmacological inhibition of LSD1 has been reported to significantly attenuate tumor progression in vitro and in vivo in a range of solid tumors and acute myeloid leukemia. This review will present the structural aspects of LSD1, its role in carcinogenesis, a comparison of currently available approaches for screening LSD1 inhibitors, a classification of LSD1 inhibitors, and its potential as a drug target in cancer therapy.
KeywordLSD1 demethylase histone breast cancer prostate cancer acute myeloid leukemia cancer therapy
DOI10.3390/molecules23123194
URLView the original
Indexed BySCI
Language英语
WOS Research AreaBiochemistry & Molecular Biology ; Chemistry
WOS SubjectBiochemistry & Molecular Biology ; Chemistry, Multidisciplinary
WOS IDWOS:000454523000144
PublisherMDPI
Fulltext Access
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Cited Times [WOS]:7   [WOS Record]     [Related Records in WOS]
Document TypeJournal article
CollectionUniversity of Macau
Affiliation1.Univ Macau, Inst Chinese Med Sci, State Key Lab Qual Res Chinese Med, Macau 999078, Peoples R China;
2.Hong Kong Baptist Univ, Dept Chem, Kowloon Tong, Hong Kong 999077, Peoples R China
First Author AffilicationUniversity of Macau
Recommended Citation
GB/T 7714
Yang, Guan-Jun,Lei, Pui-Man,Wong, Suk-Yu,et al. Pharmacological Inhibition of LSD1 for Cancer Treatment[J]. MOLECULES,2018,23(12).
APA Yang, Guan-Jun,Lei, Pui-Man,Wong, Suk-Yu,Ma, Dik-Lung,&Leung, Chung-Hang.(2018).Pharmacological Inhibition of LSD1 for Cancer Treatment.MOLECULES,23(12).
MLA Yang, Guan-Jun,et al."Pharmacological Inhibition of LSD1 for Cancer Treatment".MOLECULES 23.12(2018).
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