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Dynamics of Gut Microbiome in Giant Panda Cubs Reveal Transitional Microbes and Pathways in Early Life
Guo, Min1; Chen, Jianwei2; Li, Qiongfang3; Fu, Ying4; Fan, Guangyi1,2,3; Ma, Jinmin3; Peng, Ling3; Zeng, Liyun5; Chen, Jing5; Wang, Yayu3; Lee, Simon Ming-Yuen1
2018-12-18
Source PublicationFRONTIERS IN MICROBIOLOGY
ISSN1664-302X
Volume9
AbstractAdult giant pandas (Ailuropoda melanoleuca) express transitional characteristics in that they consume bamboos, despite their carnivore-like digestive tracts. Their genome contains no cellulolytic enzymes; therefore, understanding the development of the giant panda gut microbiome, especially in early life, is important for decoding the rules underlying gut microbial formation, inheritance and dietary transitions. With deep metagenomic sequencing, we investigated the gut microbiomes of two newborn giant panda brothers and their parents living in Macao, China, from 2016 to 2017. Both giant panda cubs exhibited progressive increases in gut microbial richness during growth, particularly from the 6th month after birth. Enterobacteriaceae dominated the gut microbial compositions in both adult giant pandas and cubs. A total of 583 co-abundance genes (CAGs) and about 79 metagenomic species (MGS) from bacteria or viruses displayed significant changes with age. Seven genera (Shewanella, Oblitimonas, Helicobacter, Haemophilus, Aeromonas, Listeria, and Fusobacterium) showed great importance with respect to gut microbial structural determination in the nursing stage of giant panda cubs. Furthermore, 10 orthologous gene functions and 44 pathways showed significant changes with age. Of the significant pathways, 16 from Escherichia, Klebsiella, Propionibacterium, Lactobacillus, and Lactococcus displayed marked differences between parents and their cubs at birth, while 29 pathways from Escherichia, Campylobacter and Lactobacillus exhibited significant increase in cubs from 6 to 9 months of age. In addition, oxidoreductases, transferases, and hydrolases dominated the significantly changed gut microbial enzymes during the growth of giant panda cubs, while few of them were involved in cellulose degradation. The findings indicated diet-stimulated gut microbiome transitions and the important role of Enterobacteriaceae in the guts of giant panda in early life.
Keywordgiant panda cubs gut microbiota co-abundance genes important microbes gut microbial gene functions and pathways
DOI10.3389/fmicb.2018.03138
URLView the original
Indexed BySCI
Language英语
WOS Research AreaMicrobiology
WOS SubjectMicrobiology
WOS IDWOS:000453656500001
PublisherFRONTIERS MEDIA SA
Fulltext Access
Citation statistics
Document TypeJournal article
CollectionUniversity of Macau
Affiliation1.Univ Macau, State Key Lab Qual Res Chinese Med, Inst Chinese Med Sci, Macau, Peoples R China;
2.BGI Qingdao, BGI Shenzhen, Qingdao, Peoples R China;
3.BGI Shenzhen, Shenzhen, Peoples R China;
4.Univ Macau, Fac Sci & Technol, Macau, Peoples R China;
5.Realbio Genom Inst, Shanghai, Peoples R China
First Author AffilicationUniversity of Macau
Recommended Citation
GB/T 7714
Guo, Min,Chen, Jianwei,Li, Qiongfang,et al. Dynamics of Gut Microbiome in Giant Panda Cubs Reveal Transitional Microbes and Pathways in Early Life[J]. FRONTIERS IN MICROBIOLOGY,2018,9.
APA Guo, Min.,Chen, Jianwei.,Li, Qiongfang.,Fu, Ying.,Fan, Guangyi.,...&Lee, Simon Ming-Yuen.(2018).Dynamics of Gut Microbiome in Giant Panda Cubs Reveal Transitional Microbes and Pathways in Early Life.FRONTIERS IN MICROBIOLOGY,9.
MLA Guo, Min,et al."Dynamics of Gut Microbiome in Giant Panda Cubs Reveal Transitional Microbes and Pathways in Early Life".FRONTIERS IN MICROBIOLOGY 9(2018).
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