A pH-driven ring translocation switch against cancer cells

doi:10.1039/c8cc08681h

UM > 中華醫藥研究院

	A pH-driven ring translocation switch against cancer cells
	Cheng, Qian 1; Yin, Hang 1; Rosas, Roselyne 2; Gigmes, Didier 3; Ouari, Olivier 3; Wang, Ruibing1 ; Kermagoret, Anthony 3; Bardelang, David 3
	2018-12-21
Source Publication	CHEMICAL COMMUNICATIONS
ISSN	1359-7345
Volume	54 Issue:98 Pages:13825-13828
Abstract	A molecular switch built with cucurbit[7]uril and a 3-station viologen-phenylene-imidazole compound exhibited pH actuated ring translocation with high fatigue resistance (up to 10(2) cycles). The switch movement was harnessed toward selectively masking the toxicity of the viologen fragment at neutral pH near non-cancerous cells, while exposing it at acid pH near cancer cells.
DOI	10.1039/c8cc08681h
URL	View the original
Indexed By	SCI
Language	英语
WOS Research Area	Chemistry
WOS Subject	Chemistry, Multidisciplinary
WOS ID	WOS:000452480600010
Publisher	ROYAL SOC CHEMISTRY
Fulltext Access	View Full-Text via DOI View Full-Text via Web of Science
Citation statistics	Cited Times [WOS]:2 [WOS Record] [Related Records in WOS]
Document Type	Journal article
Collection	Institute of Chinese Medical Sciences
Affiliation	1.Univ Macau, Inst Chinese Med Sci, State Key Lab Qual Res Chinese Med, Ave Univ, Taipa, Macau, Peoples R China; 2.Aix Marseille Univ, CNRS, Spectropole, FR 1739, Marseille, France; 3.Aix Marseille Univ, CNRS, ICR, Marseille, France
First Author Affilication	University of Macau
Recommended Citation GB/T 7714	Cheng, Qian,Yin, Hang,Rosas, Roselyne,et al. A pH-driven ring translocation switch against cancer cells[J]. CHEMICAL COMMUNICATIONS,2018,54(98):13825-13828.
APA	Cheng, Qian.,Yin, Hang.,Rosas, Roselyne.,Gigmes, Didier.,Ouari, Olivier.,...&Bardelang, David.(2018).A pH-driven ring translocation switch against cancer cells.CHEMICAL COMMUNICATIONS,54(98),13825-13828.
MLA	Cheng, Qian,et al."A pH-driven ring translocation switch against cancer cells".CHEMICAL COMMUNICATIONS 54.98(2018):13825-13828.

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