UM
F-18-FDG-PET/CT-guided intensity-modulated radiotherapy for 42 FIGO III/IV ovarian cancer: A retrospective study
Dang, Ya-Zheng1; Li, Xin1; Ma, Yu-Xin1; Li, Xiao-Long1; Yang, Ting1; Lu, Wan-Ling1; Huang, Shi-Gao1,2
2019-01
Source PublicationONCOLOGY LETTERS
ISSN1792-1074
Volume17Issue:1Pages:149-158
AbstractThe aim of the present study was to evaluate the curative effect of fludeoxyglucose-positron emission tomography/computed tomography (F-18-FDG-PET/CT)-guided intensity-modulated radiotherapy (IMRT) for 42 patients with International Federation of Gynecology and Obstetrics (FIGO) stage III/IV ovarian cancer. Between January 2012 and December 2015, 42 patients with FIGO stage III/IV ovarian cancer who were treated with F-18-FDG-PET/CT-guided IMRT at the Department of Radiation Oncology were analyzed. A total of 21 patients who exhibited recurrence following surgery and 11 patients who were unable to tolerate or rejected surgery received 5-10 cycles of chemotherapy only. A total of 10 patients, who were either older (>70 years) or in poor general health were unable to undergo surgery and only received IMRT. The patients received a total radiation dose of 5,040 cGy (range, 4,500-5,500 cGy), with a dose fraction of 200 cGy/fx, administered a total of 10-14 times, 5 times/week, prior to being rested for half an hour to relocate lesions and undergoing a second round of radiotherapy for 10-14 cycles. The 1-, 2- and 3-year progression-free survival (PFS) rates of the patients were 66.7, 33.3 and 21.4%, respectively, and the median PFS time was 20.3 months. The 1-, 2- and 3-year local control rates of the patients were 90.5, 83.3 and 69.0%, respectively, and the 1-, 2- and 3-year overall survival (OS) rates were 73.8, 64.3 and 52.4%, respectively. According to the results of multivariate analysis using the Cox proportional hazards model, the Karnofsky performance status (KPS) score (1) was the only index associated with prognosis (P<0.003). The study concluded that for patients with advanced ovarian cancer, particularly for patients unable to undergo surgery or chemotherapy, F-18-FDG PET/CT-guided IMRT is a safe and effective treatment method, and it may be considered as an equally effective treatment option. Furthermore, the results of the present study suggested that the KPS score of a patient is the only factor affecting the OS time.
Keywordovarian cancer radiation therapy positron emission tomography computed tomography intensity-modulated radiotherapy
DOI10.3892/ol.2018.9601
URLView the original
Indexed BySCI
Language英语
WOS Research AreaOncology
WOS SubjectOncology
WOS IDWOS:000454845500019
PublisherSPANDIDOS PUBL LTD
Fulltext Access
Citation statistics
Document TypeJournal article
CollectionUniversity of Macau
Affiliation1.Peoples Liberat Army Air Force, Hosp 986, Dept Radiat Oncol, Xian 710054, Shaanxi, Peoples R China;
2.Univ Macau, Fac Hlth Sci, Ave Univ, Taipa, Macao, Peoples R China
Recommended Citation
GB/T 7714
Dang, Ya-Zheng,Li, Xin,Ma, Yu-Xin,et al. F-18-FDG-PET/CT-guided intensity-modulated radiotherapy for 42 FIGO III/IV ovarian cancer: A retrospective study[J]. ONCOLOGY LETTERS,2019,17(1):149-158.
APA Dang, Ya-Zheng.,Li, Xin.,Ma, Yu-Xin.,Li, Xiao-Long.,Yang, Ting.,...&Huang, Shi-Gao.(2019).F-18-FDG-PET/CT-guided intensity-modulated radiotherapy for 42 FIGO III/IV ovarian cancer: A retrospective study.ONCOLOGY LETTERS,17(1),149-158.
MLA Dang, Ya-Zheng,et al."F-18-FDG-PET/CT-guided intensity-modulated radiotherapy for 42 FIGO III/IV ovarian cancer: A retrospective study".ONCOLOGY LETTERS 17.1(2019):149-158.
Related Services
Recommend this item
Bookmark
Usage statistics
Export to Endnote
Google Scholar
Similar articles in Google Scholar
[Dang, Ya-Zheng]'s Articles
[Li, Xin]'s Articles
[Ma, Yu-Xin]'s Articles
Baidu academic
Similar articles in Baidu academic
[Dang, Ya-Zheng]'s Articles
[Li, Xin]'s Articles
[Ma, Yu-Xin]'s Articles
Bing Scholar
Similar articles in Bing Scholar
[Dang, Ya-Zheng]'s Articles
[Li, Xin]'s Articles
[Ma, Yu-Xin]'s Articles
Terms of Use
No data!
Social Bookmark/Share
All comments (0)
No comment.
 

Items in the repository are protected by copyright, with all rights reserved, unless otherwise indicated.