UM
Brij-grafted-chitosan copolymers with function of P-glycoprotein modulation: Synthesis, characterization and in vitro investigations
Xiong, Wei1; Zhao, Guan Ding1; Yin, Xunqing2; Gang, Ke Linghu1; Chu, John M. T.3; Wong, Gordon T. C.3; Li, Haifeng2; Yu, Hua1,4,5; Wang, Yi Tao1
2019-01-15
Source PublicationCARBOHYDRATE POLYMERS
ISSN0144-8617
Volume204Pages:89-96
AbstractChitosan (CS), a nature-derived polysaccharide, is a promising nano-carrier material with good biocompatibility and biodegradability. However, the biomedical applications of CS are hindered because of its poor aqueous solubility. To circumvent this drawback, a series of Brij-grafted-chitosan copolymers (BCs) with various grafting degree of Brij-S20 were first developed and reported. The results indicated that the water solubility of BCs (from 9.13 to 9.54 mg/mL) were much higher than that of CS (0.32 mg/mL), due to the broken intra-and/or intermolecular hydrogen bonds and the decreased initial crystallinity in BCs. The amphiphilic structure of BCs presented lower critical micelle concentration (0.116-0.376 mg/mL) thus facilitating its self-aggregation into micelles for drug encapsulation. Moreover, BCs markedly enhanced the intracellular uptake of rhodamine-123 in MDCK-MDR1 cells. This inhibition on Pgp-mediated efflux was also confirmed by confocal microscopy. In conclusion, BCs could be further developed as polymeric nano-carriers for those drugs with Pgp-mediated efflux.
KeywordChitosan Brij-S20 Solubility P-Glycoprotein Drug efflux
DOI10.1016/j.carbpol.2018.10.007
URLView the original
Indexed BySCI
Language英语
WOS Research AreaChemistry ; Polymer Science
WOS SubjectChemistry, Applied ; Chemistry, Organic ; Polymer Science
WOS IDWOS:000448147100011
PublisherELSEVIER SCI LTD
Fulltext Access
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Cited Times [WOS]:2   [WOS Record]     [Related Records in WOS]
Document TypeJournal article
CollectionUniversity of Macau
Affiliation1.Univ Macau, Inst Chinese Med Sci, State Key Lab Qual Res Chinese Med, Taipa, Macao, Peoples R China;
2.Univ Macau, Inst Appl Phys & Mat Engn, Taipa, Macao, Peoples R China;
3.Univ Hong Kong, LKS Fac Med, Dept Anaesthesiol, Pokfulam, Hong Kong, Peoples R China;
4.Hong Kong Baptist Univ, Shenzhen Res Ctr, Shenzhen, Guangdong, Peoples R China;
5.Hong Kong Baptist Univ, Sch Chinese Med, Kowloon Tong, Hong Kong, Peoples R China
First Author AffilicationUniversity of Macau
Recommended Citation
GB/T 7714
Xiong, Wei,Zhao, Guan Ding,Yin, Xunqing,et al. Brij-grafted-chitosan copolymers with function of P-glycoprotein modulation: Synthesis, characterization and in vitro investigations[J]. CARBOHYDRATE POLYMERS,2019,204:89-96.
APA Xiong, Wei.,Zhao, Guan Ding.,Yin, Xunqing.,Gang, Ke Linghu.,Chu, John M. T..,...&Wang, Yi Tao.(2019).Brij-grafted-chitosan copolymers with function of P-glycoprotein modulation: Synthesis, characterization and in vitro investigations.CARBOHYDRATE POLYMERS,204,89-96.
MLA Xiong, Wei,et al."Brij-grafted-chitosan copolymers with function of P-glycoprotein modulation: Synthesis, characterization and in vitro investigations".CARBOHYDRATE POLYMERS 204(2019):89-96.
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