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Discovery of a Novel ERp57 Inhibitor as Antiplatelet Agent from Danshen (Salvia miltiorrhiza)
Zou, Jia1; Chen, Yang1; Hoi, Maggie Pui Man1; Li, Jun2; Wang, Tao1; Zhang, Ying1; Feng, Yu2; Gao, Jianli3; Lee, Simon Ming Yuen2; Cui, Guozhen1
2018
Source PublicationEVIDENCE-BASED COMPLEMENTARY AND ALTERNATIVE MEDICINE
ISSN1741-427X
Abstract

Danshen (Salvia miltiorrhiza) is a well-known herb in Traditional Chinese Medicine (TCM) for treating cardiovascular diseases, but the underlying mechanism remains to be fully elucidated. Here, we showed that Danshen and its active ingredient rosmarinic acid exhibited antiplatelet effects through the inhibition of ERp57, a member of protein disulfide isomerase (PDI) with potential roles in platelet aggregation. Danshen extract (DSE) exhibited potent inhibitory effects on the platelet aggregation induced by arachidonic acid-(AA-) induced platelet aggregation and the enzymatic activity of ERp57. Rosmarinic acid was identified by virtual screening and molecular docking as one of the hit compounds for ERp57. In line with this, rosmarinic acid displayed significant inhibitory effect on ERp57 activity and inhibited AA-induced platelet aggregation. Taken together, we demonstrated for the first time that DSE and rosmarinic acid displayed inhibitory effects on the catalytic activity of ERp57, providing evidence of the regulatory role of ERp57 underlying the antiplatelet effects of Danshen.

DOI10.1155/2018/9387568
URLView the original
Indexed BySCI
Language英语
WOS Research AreaIntegrative & Complementary Medicine
WOS SubjectIntegrative & Complementary Medicine
WOS IDWOS:000431581800001
PublisherHINDAWI LTD
The Source to ArticleWOS
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Cited Times [WOS]:1   [WOS Record]     [Related Records in WOS]
Document TypeJournal article
CollectionInstitute of Chinese Medical Sciences
Corresponding AuthorChen, Yang; Cui, Guozhen
Affiliation1.Zhuhai Key Laboratory of Basic and Applied Research in Chinese Medicine, Department of Bioengineering, Zunyi Medical University, Zhuhai Campus, Zhuhai, China
2.State Key Laboratory of Quality Research in Chinese Medicine and Institute of Chinese Medical Sciences, University of Macau, Macau
3.Academy of Traditional Chinese Medicine, Zhejiang Chinese Medical University, Hangzhou, Zhejiang 310053, China
Recommended Citation
GB/T 7714
Zou, Jia,Chen, Yang,Hoi, Maggie Pui Man,et al. Discovery of a Novel ERp57 Inhibitor as Antiplatelet Agent from Danshen (Salvia miltiorrhiza)[J]. EVIDENCE-BASED COMPLEMENTARY AND ALTERNATIVE MEDICINE,2018.
APA Zou, Jia.,Chen, Yang.,Hoi, Maggie Pui Man.,Li, Jun.,Wang, Tao.,...&Cui, Guozhen.(2018).Discovery of a Novel ERp57 Inhibitor as Antiplatelet Agent from Danshen (Salvia miltiorrhiza).EVIDENCE-BASED COMPLEMENTARY AND ALTERNATIVE MEDICINE.
MLA Zou, Jia,et al."Discovery of a Novel ERp57 Inhibitor as Antiplatelet Agent from Danshen (Salvia miltiorrhiza)".EVIDENCE-BASED COMPLEMENTARY AND ALTERNATIVE MEDICINE (2018).
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