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Lipidomic-based investigation into the regulatory effect of Schisandrin B on palmitic acid level in non-alcoholic steatotic livers
Kwan H.Y.1; Niu X.6; Dai W.1; Tong T.1; Chao X.1; Su T.1; Chan C.L.1; Lee K.C.2; Fu X.1; Yi H.7; Yu H.1; Li T.1; Tse A.K.W.1; Fong W.F.1; Pan S.-Y.4; Lu A.1; Yu Z.-L.1
2015-03-13
Source PublicationScientific Reports
ISSN20452322
Volume5
Abstract

Schisandrin B (SchB) is one of the most abundant bioactive dibenzocyclooctadiene derivatives found in the fruit of Schisandra chinensis. Here, we investigated the potential therapeutic effects of SchB on non-alcoholic fatty-liver disease (NAFLD). In lipidomic study, ingenuity pathway analysis highlighted palmitate biosynthesis metabolic pathway in the liver samples of SchB-treated high-fat-diet-fed mice. Further experiments showed that the SchB treatment reduced expression and activity of fatty acid synthase, expressions of hepatic mature sterol regulatory element binding protein-1 and tumor necrosis factor-α, and hepatic level of palmitic acid which is known to promote progression of steatosis to steatohepatitis. Furthermore, the treatment also reduced hepatic fibrosis, activated nuclear factor-erythroid-2-related factor-2 which is known to attenuate the progression of NASH-related fibrosis. Interestingly, in fasting mice, a single high-dose SchB induced transient lipolysis and increased the expressions of adipose triglyceride lipase and phospho-hormone sensitive lipase. The treatment also increased plasma cholesterol levels and 3-hydroxy-3-methylglutaryl-CoA reductase activity, reduced the hepatic low-density-lipoprotein receptor expression in these mice. Our data not only suggest SchB is a potential therapeutic agent for NAFLD, but also provided important information for a safe consumption of SchB because SchB overdosed under fasting condition will have adverse effects on lipid metabolism.

DOI10.1038/srep09114
URLView the original
Indexed BySCI
Language英语
WOS Research AreaScience & Technology - Other Topics
WOS SubjectMultidisciplinary Sciences
WOS IDWOS:000351155000004
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Cited Times [WOS]:15   [WOS Record]     [Related Records in WOS]
Document TypeJournal article
CollectionInstitute of Chinese Medical Sciences
Affiliation1.Hong Kong Baptist University
2.Hong Kong Polytectinic University
3.HKBU Institute of Research and Continuing Education
4.Beijing University of Chinese Medicine
5.The University of Hong Kong
6.China Academy of Chinese Medical Sciences
7.Guangzhou University of Traditional Chinese Medicine
Recommended Citation
GB/T 7714
Kwan H.Y.,Niu X.,Dai W.,et al. Lipidomic-based investigation into the regulatory effect of Schisandrin B on palmitic acid level in non-alcoholic steatotic livers[J]. Scientific Reports,2015,5.
APA Kwan H.Y..,Niu X..,Dai W..,Tong T..,Chao X..,...&Yu Z.-L..(2015).Lipidomic-based investigation into the regulatory effect of Schisandrin B on palmitic acid level in non-alcoholic steatotic livers.Scientific Reports,5.
MLA Kwan H.Y.,et al."Lipidomic-based investigation into the regulatory effect of Schisandrin B on palmitic acid level in non-alcoholic steatotic livers".Scientific Reports 5(2015).
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