UM  > 健康科學學院
Bcl3 Phosphorylation by Akt, Erk2, and IKK Is Required for Its Transcriptional Activity
Vivien Ya-Fan Wang1,2; Yidan Li2; Daniel Kim2; Xiangyang Zhong2; Qian Du2; Majid Ghassemian2; Gourisankar Ghosh2
2017
Source PublicationMOLECULAR CELL
ISSN1097-2765
Volume67Issue:3Pages:484-497.e1-e5
Other Abstract

Unlike prototypical IκB proteins, which are inhibitors of NF-κB RelA, cRel, and RelB dimers, the atypical IκB protein Bcl3 is primarily a transcriptional coregulator of p52 and p50 homodimers. Bcl3 exists as phospho-protein in many cancer cells. Unphosphorylated Bcl3 acts as a classical IκB-like inhibitor and removes p50 and p52 from bound DNA. Neither the phosphorylation site(s) nor the kinase(s) phosphorylating Bcl3 is known. Here we show that Akt, Erk2, and IKK1/2 phosphorylate Bcl3. Phosphorylation of Ser33 by Akt induces switching of K48 ubiquitination to K63 ubiquitination and thus promotes nuclear localization and stabilization of Bcl3. Phosphorylation by Erk2 and IKK1/2 of Ser114 and Ser446 converts Bcl3 into a transcriptional coregulator by facilitating its recruitment to DNA. Cells expressing the S114A/S446A mutant have cellular proliferation and migration defects. This work links Akt and MAPK pathways to NF-κB through Bcl3 and provides mechanistic insight into how Bcl3 functions as an oncoprotein through collaboration with IKK1/2, Akt, and Erk2.

DOIhttps://doi.org/10.1016/j.molcel.2017.06.011
Indexed BySCI
Language英语
WOS Research AreaBiochemistry & Molecular Biology ; Cell Biology
WOS SubjectBiochemistry & Molecular Biology ; Cell Biology
WOS IDWOS:000406861800013
Fulltext Access
Citation statistics
Cited Times [WOS]:11   [WOS Record]     [Related Records in WOS]
Document TypeJournal article
CollectionFaculty of Health Sciences
Corresponding AuthorGourisankar Ghosh
Affiliation1.Faculty of Health Sciences, University of Macau, Avenida da Universidade, Taipa, Macau SAR, China
2.Department of Chemistry and Biochemistry, University of California, San Diego, 9500 Gilman Drive, La Jolla, CA, USA
First Author AffilicationFaculty of Health Sciences
Recommended Citation
GB/T 7714
Vivien Ya-Fan Wang,Yidan Li,Daniel Kim,et al. Bcl3 Phosphorylation by Akt, Erk2, and IKK Is Required for Its Transcriptional Activity[J]. MOLECULAR CELL,2017,67(3):484-497.e1-e5.
APA Vivien Ya-Fan Wang.,Yidan Li.,Daniel Kim.,Xiangyang Zhong.,Qian Du.,...&Gourisankar Ghosh.(2017).Bcl3 Phosphorylation by Akt, Erk2, and IKK Is Required for Its Transcriptional Activity.MOLECULAR CELL,67(3),484-497.e1-e5.
MLA Vivien Ya-Fan Wang,et al."Bcl3 Phosphorylation by Akt, Erk2, and IKK Is Required for Its Transcriptional Activity".MOLECULAR CELL 67.3(2017):484-497.e1-e5.
Related Services
Recommend this item
Bookmark
Usage statistics
Export to Endnote
Google Scholar
Similar articles in Google Scholar
[Vivien Ya-Fan Wang]'s Articles
[Yidan Li]'s Articles
[Daniel Kim]'s Articles
Baidu academic
Similar articles in Baidu academic
[Vivien Ya-Fan Wang]'s Articles
[Yidan Li]'s Articles
[Daniel Kim]'s Articles
Bing Scholar
Similar articles in Bing Scholar
[Vivien Ya-Fan Wang]'s Articles
[Yidan Li]'s Articles
[Daniel Kim]'s Articles
Terms of Use
No data!
Social Bookmark/Share
All comments (0)
No comment.
 

Items in the repository are protected by copyright, with all rights reserved, unless otherwise indicated.