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Decoding the role of TET family dioxygenases in lineage specification
Wu, XW; Li, G; Xie, RY

Since the discovery of methylcytosine oxidase ten-eleven translocation (TET) proteins, we have witnessed an exponential increase in studies examining their roles in epigenetic regulation. TETfamily proteins catalyze the sequential oxidation of 5-methylcytosine (5mC) to oxidized methylcytosines including 5-hydroxymethylcytosine (5hmC), 5-formylcytosine, and 5-carboxylcytosine. TETs contribute to the regulation of lineage-specific gene expression via modulating DNA 5mC/5hmC balances at the proximal and distal regulatory elements of cell identity genes, and therefore enhance chromatin accessibility and gene transcription. Emerging evidence suggests that TET dioxygenases participate in the establishment and/or maintenance ofhypomethylated bivalent domains at multiple differentiation-associated genes, and thus ensure developmental plasticity. Here, we review the current state of knowledge concerning TET familyproteins, DNA hydroxymethylation, their distribution, and function in endoderm, mesoderm, and neuroectoderm specification. We will summarize the evidence pertaining to their crucial regulatory roles in lineage commitment and development.

KeywordLineage Specification Tet Enhancer Bivalent Promoter 5mc 5hmc
DOI 10.1186/s13072-018-0228-7
Indexed BySCI
WOS Research AreaGenetics & Heredity
WOS SubjectGenetics & Heredity
WOS IDWOS:000449561200001
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Document TypeJournal article
CollectionFaculty of Health Sciences
AffiliationUniv Macau, Ctr Reprod Dev & Aging, Fac Hlth Sci, Macau 999078, Peoples R China
First Author AffilicationUniversity of Macau
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GB/T 7714
Wu, XW,Li, G,Xie, RY. Decoding the role of TET family dioxygenases in lineage specification[J]. EPIGENETICS & CHROMATIN,2018,11.
APA Wu, XW,Li, G,&Xie, RY.(2018).Decoding the role of TET family dioxygenases in lineage specification.EPIGENETICS & CHROMATIN,11.
MLA Wu, XW,et al."Decoding the role of TET family dioxygenases in lineage specification".EPIGENETICS & CHROMATIN 11(2018).
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