UM
Antigen loading on dendritic cells affects the cell function in stimulating T cells
Wang Y.; Xie W.; Qiu Y.; Gu Z.; Zhang X.
2000
Source PublicationZhonghua xue ye xue za zhi = Zhonghua xueyexue zazhi
ISSN02532727
Volume21Issue:7Pages:345-348
AbstractOBJECTIVE: To study the effect of antigen loading on dendritic cells (DC). METHODS: DCs collected from peripheral blood monocytes were loaded with a tumor antigen from XG-7 cell line. These DCs were then co-cultured with allogeneic T cells and were compared with those DCs without antigen exposure. RESULTS: Although DCs showed no change in their phenotypes after cultured with the antigen, they secreted more IL-12, and became more powerful in allogenic mixed lymphocyte reaction (MLR). Antigen-loaded DC stimulated more CD(4)(+) cells to proliferate than nonantigen-loaded DCs did. These CD(4)(+) cells did not kill XG-7 cells, but promoted CD(8)(+) cells' ability to inhibit the XG-7 proliferation. CONCLUSION: The proliferation of CD(4)(+) cells after cultured with DC may become an indicator for the function of antigen loaded DC and for the efficiency of DC immunotherapy.
URLView the original
Language英語
Fulltext Access
Document TypeJournal article
CollectionUniversity of Macau
AffiliationSuzhou Medical University
Recommended Citation
GB/T 7714
Wang Y.,Xie W.,Qiu Y.,et al. Antigen loading on dendritic cells affects the cell function in stimulating T cells[J]. Zhonghua xue ye xue za zhi = Zhonghua xueyexue zazhi,2000,21(7):345-348.
APA Wang Y.,Xie W.,Qiu Y.,Gu Z.,&Zhang X..(2000).Antigen loading on dendritic cells affects the cell function in stimulating T cells.Zhonghua xue ye xue za zhi = Zhonghua xueyexue zazhi,21(7),345-348.
MLA Wang Y.,et al."Antigen loading on dendritic cells affects the cell function in stimulating T cells".Zhonghua xue ye xue za zhi = Zhonghua xueyexue zazhi 21.7(2000):345-348.
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