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A novel FGFR1-binding peptide exhibits anti-tumor effect on lung cancer by inhibiting proliferation and angiogenesis
Tan, Qiaoyan1; Wang, Zuqiang1; Wang, Quan1; Wang, Yuanqiang2; Huang, Zhifeng3; Su, Nan1; Jin, Min1; Kuang, Liang1; Qi, Huabing1; Ni, Zhenhong1; Li, Can1; Zhu, Ying1; Jiang, Wanling1; Chen, Hangang1; Deng, Chuxia4; Du, Xiaolan1; Xie, Yangli1; Chen, Lin1
2018
Source PublicationINTERNATIONAL JOURNAL OF BIOLOGICAL SCIENCES
ISSN1449-2288
Volume14Issue:10Pages:1389-1398
Abstract

It has been reported that overactivation of fibroblast growth factor receptor 1 (FGFR1) is an important characteristic found in most non-small cell lung cancer (NSCLC) samples. Here, we identified a FGFR1 inhibitory peptide R1-P2 and investigated its effects on the lung cancer cells growth and angiogenesis in vitro and in vivo. Our results demonstrate that R1-P2 bound to human FGFR1 protein, and efficiently blocked the binding of FGF2 to FGFR1 in A549 and NCI-H460 cells. Moreover, this peptide significantly decreased the proliferation, migration and invasion, but promoted the apoptosis in both cell lines. In addition, R1-P2 treatment effectively inhibited the tumor growth and neovascularization in nude mice with xenografted A549 cells, and R1-P2 also significantly inhibited the FGF2-induced angiogenesis in tube formation experiment and CAM model. We further demonstrated that R1-P2 suppressed lung tumor growth through anti-angiogenic and anti-proliferative activity. Our data may provide a novle leading molecule with potential application in the treatment of FGFR1 activation related lung cancers.

KeywordPhage Display Fgfr1 Peptide Cancer Therapy Lung Cancer
DOIhttp://doi.org/10.7150/ijbs.24739
URLView the original
Indexed BySCI
Language英语
WOS Research AreaBiochemistry & Molecular Biology ; Life Sciences & Biomedicine - Other Topics
WOS SubjectBiochemistry & Molecular Biology ; Biology
WOS IDWOS:000441909000020
PublisherIVYSPRING INT PUBL
The Source to ArticleWOS
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Cited Times [WOS]:2   [WOS Record]     [Related Records in WOS]
Document TypeJournal article
CollectionFaculty of Health Sciences
Co-First AuthorTan, Qiaoyan
Corresponding AuthorDu, Xiaolan; Xie, Yangli; Chen, Lin
Affiliation1.Department of Rehabilitation Medicine, Center of Bone Metabolism and Repair, State Key Laboratory of Trauma, Burns and Combined Injury, Trauma Center, Research Institute of Surgery, Daping Hospital, Third Military Medical University, Chongqing, China.
2.College of Bioengineering, Chongqing Institute of Technology, Chongqing, China
3.School of Pharmacy, Wenzhou Medical University, Wenzhou, China.
4.Faculty of Health Sciences, University of Macau, Macau SAR, China.
Recommended Citation
GB/T 7714
Tan, Qiaoyan,Wang, Zuqiang,Wang, Quan,et al. A novel FGFR1-binding peptide exhibits anti-tumor effect on lung cancer by inhibiting proliferation and angiogenesis[J]. INTERNATIONAL JOURNAL OF BIOLOGICAL SCIENCES,2018,14(10):1389-1398.
APA Tan, Qiaoyan.,Wang, Zuqiang.,Wang, Quan.,Wang, Yuanqiang.,Huang, Zhifeng.,...&Chen, Lin.(2018).A novel FGFR1-binding peptide exhibits anti-tumor effect on lung cancer by inhibiting proliferation and angiogenesis.INTERNATIONAL JOURNAL OF BIOLOGICAL SCIENCES,14(10),1389-1398.
MLA Tan, Qiaoyan,et al."A novel FGFR1-binding peptide exhibits anti-tumor effect on lung cancer by inhibiting proliferation and angiogenesis".INTERNATIONAL JOURNAL OF BIOLOGICAL SCIENCES 14.10(2018):1389-1398.
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