UM
Developmental regulation of β-1,3-galactosyltransferase-1 gene expression in mouse brain
Zhu D.2; Shen A.1; Wang Y.2; Gu X.1; Gu J.2
2003-03-13
Source PublicationFEBS Letters
ISSN00145793
Volume538Issue:1-3Pages:163-167
Abstractβ-1,3-galactosyltransferase-1 (β3GalT-1) is the key enzyme to form the type 1 chain structure. Northern blot analysis indicated that β3GalT-1 was expressed predominantly in the brain. In the present study, it was revealed that the gene expression of β3GalT-1 in mouse brain was developmentally decreased. High expression levels of β3GalT-1 were found in cerebral cortex and hippocampus in both newborn and adult mice, while in cerebellum, the expression levels decreased markedly during development. In situ hybridization revealed that the absence of expression in cerebellar granual cell layers contributed to the main loss of β3GalT-1 expression in adult mouse cerebellum. Moreover, the decreased levels of β3GalT-1could affect the synthesis of type 1 chain oligosaccharides, as revealed by immunohistochemistry analysis. © 2003 Federation of European Biochemical Societies. Published by Elsevier Science B.V. All rights reserved.
KeywordGalactosyltransferase Gene expression Mouse brain
DOI10.1016/S0014-5793(03)00168-6
URLView the original
Language英語
Fulltext Access
Citation statistics
Cited Times [WOS]:6   [WOS Record]     [Related Records in WOS]
Document TypeJournal article
CollectionUniversity of Macau
Affiliation1.Nantong Medical College
2.Fudan University Shanghai Medical College
Recommended Citation
GB/T 7714
Zhu D.,Shen A.,Wang Y.,et al. Developmental regulation of β-1,3-galactosyltransferase-1 gene expression in mouse brain[J]. FEBS Letters,2003,538(1-3):163-167.
APA Zhu D.,Shen A.,Wang Y.,Gu X.,&Gu J..(2003).Developmental regulation of β-1,3-galactosyltransferase-1 gene expression in mouse brain.FEBS Letters,538(1-3),163-167.
MLA Zhu D.,et al."Developmental regulation of β-1,3-galactosyltransferase-1 gene expression in mouse brain".FEBS Letters 538.1-3(2003):163-167.
Files in This Item:
There are no files associated with this item.
Related Services
Recommend this item
Bookmark
Usage statistics
Export to Endnote
Google Scholar
Similar articles in Google Scholar
[Zhu D.]'s Articles
[Shen A.]'s Articles
[Wang Y.]'s Articles
Baidu academic
Similar articles in Baidu academic
[Zhu D.]'s Articles
[Shen A.]'s Articles
[Wang Y.]'s Articles
Bing Scholar
Similar articles in Bing Scholar
[Zhu D.]'s Articles
[Shen A.]'s Articles
[Wang Y.]'s Articles
Terms of Use
No data!
Social Bookmark/Share
All comments (0)
No comment.
 

Items in the repository are protected by copyright, with all rights reserved, unless otherwise indicated.