UM
An alternative form of paraptosis-like cell death, triggered by TAJ/TROY and enhanced by PDCD5 overexpression
Wang Y.; Li X.; Wang L.; Ding P.; Zhang Y.; Han W.; Ma D.
2004-03-15
Source PublicationJournal of Cell Science
ISSN00219533
Volume117Issue:8Pages:1525-1532
AbstractAccumulating reports demonstrate that apoptosis does not explain all the forms of programmed cell death (PCD), particularly in individual development and neurodegenerative disease. Recently, a novel type of PCD, designated 'paraptosis', was described. Here, we show that overexpression of TAJ/TROY, a member of the tumor necrosis factor receptor superfamily, induces non-apoptotic cell death with paraptosis-like morphology in 293T cells. Transmission electron microscopy studies reveal extensive cytoplasmic vacuolation and mitochondrial swelling in some dying cells and no condensation or fragmentation of the nuclei. Characteristically, cell death triggered by TAJ/TROY was accompanied by phosphatidylserine externalization, loss of the mitochondrial transmembrane potential and independent of caspase activation. In addition, TAJ/TROY suppressed clonogenic growth of HEK293 and HeLa cells. Interestingly, overexpression of Programmed cell death 5 (PDCD5), an apoptosis-promoting protein, enhanced TAJ/TROY-induced paraptotic cell death. Moreover, cellular endogenous PDCD5 protein was significantly upregulated in response to TAJ/TROY overexpression. These results provide novel evidence that TAJ/TROY activates a death pathway distinct from apoptosis and that PDCD5 is an important regulator in both apoptotic and non-apoptotic PCD.
KeywordNon-apoptotic Paraptosis PDCD5 TAJ/TROY TFAR19
DOI10.1242/jcs.00994
URLView the original
Language英語
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Cited Times [WOS]:156   [WOS Record]     [Related Records in WOS]
Document TypeJournal article
CollectionUniversity of Macau
AffiliationPeking University
Recommended Citation
GB/T 7714
Wang Y.,Li X.,Wang L.,et al. An alternative form of paraptosis-like cell death, triggered by TAJ/TROY and enhanced by PDCD5 overexpression[J]. Journal of Cell Science,2004,117(8):1525-1532.
APA Wang Y..,Li X..,Wang L..,Ding P..,Zhang Y..,...&Ma D..(2004).An alternative form of paraptosis-like cell death, triggered by TAJ/TROY and enhanced by PDCD5 overexpression.Journal of Cell Science,117(8),1525-1532.
MLA Wang Y.,et al."An alternative form of paraptosis-like cell death, triggered by TAJ/TROY and enhanced by PDCD5 overexpression".Journal of Cell Science 117.8(2004):1525-1532.
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