UM
A distinct lineage of CD4 T cells regulates tissue inflammation by producing interleukin 17
Park H.2; Li Z.2; Yang X.O.3; Chang S.H.3; Nurieva R.3; Wang Y.-H.3; Wang Y.2; Hood L.1; Zhu Z.4; Tian Q.1; Dong C.3
2005-11-01
Source PublicationNature Immunology
ISSN15292908 15292916
Volume6Issue:11Pages:1133-1141
AbstractInterleukin 17 (IL-17) has been linked to autoimmune diseases, although its regulation and function have remained unclear. Here we have evaluated in vitro and in vivo the requirements for the differentiation of naive CD4 T cells into effector T helper cells that produce IL-17. This process required the costimulatory molecules CD28 and ICOS but was independent of the cytokines and transcription factors required for T helper type 1 or type 2 differentiation. Furthermore, both IL-4 and interferon-γ negatively regulated T helper cell production of IL-17 in the effector phase. In vivo, antibody to IL-17 inhibited chemokine expression in the brain during experimental autoimmune encephalomyelitis, whereas overexpression of IL-17 in lung epithelium caused chemokine production and leukocyte infiltration. Thus, IL-17 expression characterizes a unique T helper lineage that regulates tissue inflammation. © 2005 Nature Publishing Group.
DOI10.1038/ni1261
URLView the original
Language英語
Fulltext Access
Citation statistics
Cited Times [WOS]:2723   [WOS Record]     [Related Records in WOS]
Document TypeJournal article
CollectionUniversity of Macau
Affiliation1.Institute for Systems Biology
2.University of Washington, Seattle
3.University of Texas MD Anderson Cancer Center
4.The Johns Hopkins School of Medicine
Recommended Citation
GB/T 7714
Park H.,Li Z.,Yang X.O.,et al. A distinct lineage of CD4 T cells regulates tissue inflammation by producing interleukin 17[J]. Nature Immunology,2005,6(11):1133-1141.
APA Park H..,Li Z..,Yang X.O..,Chang S.H..,Nurieva R..,...&Dong C..(2005).A distinct lineage of CD4 T cells regulates tissue inflammation by producing interleukin 17.Nature Immunology,6(11),1133-1141.
MLA Park H.,et al."A distinct lineage of CD4 T cells regulates tissue inflammation by producing interleukin 17".Nature Immunology 6.11(2005):1133-1141.
Related Services
Recommend this item
Bookmark
Usage statistics
Export to Endnote
Google Scholar
Similar articles in Google Scholar
[Park H.]'s Articles
[Li Z.]'s Articles
[Yang X.O.]'s Articles
Baidu academic
Similar articles in Baidu academic
[Park H.]'s Articles
[Li Z.]'s Articles
[Yang X.O.]'s Articles
Bing Scholar
Similar articles in Bing Scholar
[Park H.]'s Articles
[Li Z.]'s Articles
[Yang X.O.]'s Articles
Terms of Use
No data!
Social Bookmark/Share
All comments (0)
No comment.
 

Items in the repository are protected by copyright, with all rights reserved, unless otherwise indicated.