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Agrin is involved in lymphocytes activation that is mediated by α-dystroglycan
Zhang J.1; Wang Y.1; Chu Y.1; Su L.1; Gong Y.1; Zhang R.1; Xiong S.1
2006
Source PublicationFASEB Journal
ISSN08926638
Volume20Issue:1Pages:50-58
AbstractIt is well established that agrin, an extracellular matrix protein, plays a crucial role in the formation of neuromuscular junctions. Recent evidence indicates that agrin also contributes to immunological synapse formation. However, little is known about how agrin induces the activation of lymphocytes and whose receptors mediate its regulatory effects on these cells. In the present study, agrin was detected in lymphocytes. Up-regulation of agrin expression was involved in lymphocyte activation whereas down-regulation of its expression led to inhibition of both antigen-specific and nonspecific lymphocyte activation, indicating an intrinsic role for agrin in the activation of lymphocytes. Unexpectedly, unlike that found in muscle cells where there is coexpression of muscle-specific kinase (MuSK) and α-dystroglycan receptors for agrin, only α-dystroglycan could be detected in lymphocytes. Confocal examination showed that α-dystroglycan colocalized with agrin in forming the immunological synapse. Down-regulation of α-dystroglycan expression inhibited lymphocyte activation even in the presence of agrin. However, agrin involved in down-regulation of α-dystroglycan receptors did not increase the inhibitory effect on lymphocytes activation. The anti-α-dystroglycan antibody also induced lymphocytes activation. Taken together, these findings strongly indicate that agrin and α-dystroglycan mediate lymphocyte activation. Furthermore, agrin-involved lymphocyte activation is mediated by α-dystroglycan. © FASEB.
Keywordα-dystroglycan Agrin Immunological synapse Lymphocyte activation
DOI10.1096/fj.04-3303com
URLView the original
Language英語
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被引频次[WOS]:25   [WOS记录]     [WOS相关记录]
Document TypeJournal article
专题University of Macau
Affiliation1.Fudan University Shanghai Medical College
2.E-Institute of Shanghai Universities
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Zhang J.,Wang Y.,Chu Y.,et al. Agrin is involved in lymphocytes activation that is mediated by α-dystroglycan[J]. FASEB Journal,2006,20(1):50-58.
APA Zhang J..,Wang Y..,Chu Y..,Su L..,Gong Y..,...&Xiong S..(2006).Agrin is involved in lymphocytes activation that is mediated by α-dystroglycan.FASEB Journal,20(1),50-58.
MLA Zhang J.,et al."Agrin is involved in lymphocytes activation that is mediated by α-dystroglycan".FASEB Journal 20.1(2006):50-58.
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