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Linkage disequilibrium sharing and haplotype-tagged SNP portability between populations
Huang W.3; He Y.5; Wang H.3; Wang Y.3; Liu Y.3; Wang Y.5; Chu X.3; Wang Y.7; Xu L.3; Shen Y.3; Xiong X.3; Li H.5; Wen B.3; Qian J.5; Yuan W.3; Zhang C.3; Wang Y.3; Jiang H.3; Zhao G.3; Chen Z.3; Jin L.3
2006-01-31
Source PublicationProceedings of the National Academy of Sciences of the United States of America
ISSN00278424
Volume103Issue:5Pages:1418-1421
AbstractThe discovery of the block-like structure of linkage disequilibrium (LD) in human populations holds the promise of delineating the etiology of common diseases. However, understanding the magnitude, mechanism, and utility of between-population LD sharing is critical for future genome-wide association studies. In this study, substantial LD sharing between six non-African populations was observed, although much less between African-American and non-African, based on 20,000 SNPs of chromosome 21. We also demonstrated the respective roles of recombination and demographic events in shaping LD sharing. Furthermore, we showed that the haplotype-tagged SNPs chosen from one population are portable to the others in East Asia. Therefore, we concluded that the magnitude of LD sharing between human populations justifies the use of representative populations for selecting haplotypetagged SNPs in genome-wide association studies of complex diseases. © 2006 by The National Academy of Sciences of the USA.
KeywordAssociation study Bottleneck Common disease Genetic distance Genetic variant
DOI10.1073/pnas.0510360103
URLView the original
Language英語
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Cited Times [WOS]:23   [WOS Record]     [Related Records in WOS]
Document TypeJournal article
CollectionUniversity of Macau
Affiliation1.Shanghai South Gene Technology Co., Ltd.
2.Shanghai Biochip Co., Ltd.
3.Chinese National Human Genome Center at Shanghai
4.Shanghai Institute of Technology
5.School of Life Sciences Fudan University
6.Shanghai Institute for Biological Sciences Chinese Academy of Sciences
7.Shanghai Jiao Tong University
Recommended Citation
GB/T 7714
Huang W.,He Y.,Wang H.,et al. Linkage disequilibrium sharing and haplotype-tagged SNP portability between populations[J]. Proceedings of the National Academy of Sciences of the United States of America,2006,103(5):1418-1421.
APA Huang W..,He Y..,Wang H..,Wang Y..,Liu Y..,...&Jin L..(2006).Linkage disequilibrium sharing and haplotype-tagged SNP portability between populations.Proceedings of the National Academy of Sciences of the United States of America,103(5),1418-1421.
MLA Huang W.,et al."Linkage disequilibrium sharing and haplotype-tagged SNP portability between populations".Proceedings of the National Academy of Sciences of the United States of America 103.5(2006):1418-1421.
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