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Proteomic approach to study the cytotoxicity of dioscin (saponin)
Wang Y.1; Yim H.C.1; Yang Z.1; Chiu J.-F.1; Che C.-M.1; He Q.-Y.1
2006-04-01
Source PublicationProteomics
ISSN16159853 16159861
Volume6Issue:8Pages:2422-2432
Abstract

Dioscin, extracted from the root of Polygonatum zanlanscianense pamp, exhibits cytotoxicity towards human myeloblast leukemia HL-60 cells. Proteomic analysis revealed that the expression of mitochondrial associated proteins was substantially altered in HL-60 cells corresponding to the dioscin treatment, suggesting that mitochondria are the major cellular target of dioscin. Mitochondrial functional studies validated that mitochondrial apoptotic pathway was initiated by dioscin treatment. Changes in proteome other than mitochondrial related proteins implicate that other mechanisms were also involved in dioscin-induced apoptosis in HL-60 cells, including the activity impairment in protein synthesis, alterations of phosphatases in cell signaling, and deregulation of oxidative stress and cell proliferation. Current study of protein alterations in dioscin-treated HL-60 cells suggested that dioscin exerts cytotoxicity through multiple apoptosis-inducing pathways. © 2006 Wiley-VCH Verlag GmbH & Co. KGaA.

KeywordCytotoxicity Dioscin Drug Mechanism Hl-60 Cells Mitochondria Saponin
DOI10.1002/pmic.200500595
URLView the original
Indexed BySCI
Language英语
WOS Research AreaBiochemistry & Molecular Biology
WOS SubjectBiochemical Research Methods ; Biochemistry & Molecular Biology
WOS IDWOS:000237398700011
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被引频次[WOS]:68   [WOS记录]     [WOS相关记录]
Document TypeJournal article
专题Institute of Chinese Medical Sciences
Corresponding AuthorChe C.-M.; He Q.-Y.
Affiliation1.The University of Hong Kong
2.Shanghai Institute of Organic Chemistry Chinese Academy of Sciences
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Wang Y.,Yim H.C.,Yang Z.,et al. Proteomic approach to study the cytotoxicity of dioscin (saponin)[J]. Proteomics,2006,6(8):2422-2432.
APA Wang Y.,Yim H.C.,Yang Z.,Chiu J.-F.,Che C.-M.,&He Q.-Y..(2006).Proteomic approach to study the cytotoxicity of dioscin (saponin).Proteomics,6(8),2422-2432.
MLA Wang Y.,et al."Proteomic approach to study the cytotoxicity of dioscin (saponin)".Proteomics 6.8(2006):2422-2432.
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