UM
(-)-Epigallocatechin-3-gallate protects mice from concanavalin A-induced hepatitis through suppressing immune-mediated liver injury
Wang Y.2; Mei Y.2; Feng D.1; Xu L.2
2006-09-01
Source PublicationClinical and Experimental Immunology
ISSN00099104 13652249
Volume145Issue:3Pages:485-492
Abstract(-)-Epigallocatechin-3-gallate (EGCG) is the major active component of green tea. Increasing evidence has suggested that EGCG exhibits anti-inflammatory, anti-oxidant and immunosuppressive effects. In this study, we investigated the effect of EGCG on concanavalin A (ConA)-induced hepatitis (CIH) in mice, a model of immune-mediated liver injury in humans. We pretreated mice with EGCG before ConA injection, and then measured alanine aminotransferase (ALT) levels in plasma, inflammatory infiltration and hepatocyte apoptosis in liver. Potential therapeutic mechanisms were elucidated further by measuring several inflammatory mediators. Mice pretreated with EGCG exhibited much less increased ALT levels in plasma, reduced inflammatory infiltration and hepatocyte apoptosis in liver compared with control mice pretreated with vehicle solutions. We further investigated the mechanisms of the protective effects of EGCG. In EGCG-pretreated mice, we found abrogated tumour necrosis factor (TNF)-α and interferon (IFN)-γ at both protein levels in plasma and mRNA levels in liver. At the same time, the concentration of nitrite in plasma and inducible nitric oxide synthase production in liver were both down-regulated in these mice. Moreover, IFN-inducible protein-10 and macrophage inflammatory protein-1α expressions in liver were decreased significantly. Therefore, EGCG is capable of regulating immune-mediated liver injury in vivo. The protective effect depended on its suppressive effect on the production of important inflammatory mediators. © 2006 British Society for Immunology.
Keyword(-)-epigallocatechin-3-gallate Concanavalin A-induced hepatitis Immune-mediated liver injury
DOI10.1111/j.1365-2249.2006.03137.x
URLView the original
Language英語
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Cited Times [WOS]:22   [WOS Record]     [Related Records in WOS]
Document TypeJournal article
CollectionUniversity of Macau
Affiliation1.Shanghai Institute for Biological Sciences Chinese Academy of Sciences
2.Shanghai Jiao Tong University
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GB/T 7714
Wang Y.,Mei Y.,Feng D.,et al. (-)-Epigallocatechin-3-gallate protects mice from concanavalin A-induced hepatitis through suppressing immune-mediated liver injury[J]. Clinical and Experimental Immunology,2006,145(3):485-492.
APA Wang Y.,Mei Y.,Feng D.,&Xu L..(2006).(-)-Epigallocatechin-3-gallate protects mice from concanavalin A-induced hepatitis through suppressing immune-mediated liver injury.Clinical and Experimental Immunology,145(3),485-492.
MLA Wang Y.,et al."(-)-Epigallocatechin-3-gallate protects mice from concanavalin A-induced hepatitis through suppressing immune-mediated liver injury".Clinical and Experimental Immunology 145.3(2006):485-492.
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