UM
Autoantibodies closely relate to the elevation level of in vivo hydrogen peroxide and tissue damage in systemic lupus erythematosus
Wang Y.1; Qiao B.1; Wang Y.1; Han X.1; Chu Y.1; Xiong S.1
2006-10-01
Source PublicationDNA and Cell Biology
ISSN10445498
Volume25Issue:10Pages:563-570
AbstractRecent studies have shown that antibodies efficiently catalyze the conversion of molecular singlet oxygen (O) plus water to hydrogen peroxide (HO). HO is toxic to cells and is a cause of further free radical generation that are implicated in the pathogenesis of a variety of diseases. Systemic lupus erythematosus (SLE) is one of the most serious autoimmune diseases which are characterized by the production of various autoantibodies and subsequent tissue damage. However, the correlation of autoantibodies, HO, and tissue lesion in SLE has not been yet investigated. To address this issue, in the present study, we induced autoantibodies and kidney tissue damage by using SLE animal model as described previously. We detected the level of H O in SLE mice and found the increase of in vivo H O was accompanied and closely correlated with the production of anti-dsDNA and antihistone antibodies. Importantly, there was onefold increase of HO in the mice kidneys with apparent glomerulonephritis and IgG deposits. These results suggest that the induced autoantibodies possess catalytic activity. The produced autoantibodies lead to the production and elevation of HO, which results in subsequent renal damage and the pathogenesis of SLE. Our findings provide an insight into the understanding of SLE mechanism and provide a potential approach for therapeutic intervention of SLE. © Mary Ann Liebert, Inc.
DOI10.1089/dna.2006.25.563
URLView the original
Language英語
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Cited Times [WOS]:10   [WOS Record]     [Related Records in WOS]
Document TypeJournal article
CollectionUniversity of Macau
Affiliation1.Fudan University Shanghai Medical College
2.E-Institute of Shanghai Universities
Recommended Citation
GB/T 7714
Wang Y.,Qiao B.,Wang Y.,et al. Autoantibodies closely relate to the elevation level of in vivo hydrogen peroxide and tissue damage in systemic lupus erythematosus[J]. DNA and Cell Biology,2006,25(10):563-570.
APA Wang Y.,Qiao B.,Wang Y.,Han X.,Chu Y.,&Xiong S..(2006).Autoantibodies closely relate to the elevation level of in vivo hydrogen peroxide and tissue damage in systemic lupus erythematosus.DNA and Cell Biology,25(10),563-570.
MLA Wang Y.,et al."Autoantibodies closely relate to the elevation level of in vivo hydrogen peroxide and tissue damage in systemic lupus erythematosus".DNA and Cell Biology 25.10(2006):563-570.
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