Optical molecular imaging for systems biology: From molecule to organism
Du W.; Wang Y.; Luo Q.; Liu B.-F.
Source PublicationAnalytical and Bioanalytical Chemistry
ISSN16182642 16182650
AbstractThe development of highly efficient analytical methods capable of probing biological systems at system level is an important task that is required in order to meet the requirements of the emerging field of systems biology. Optical molecular imaging (OMI) is a very powerful tool for studying the temporal and spatial dynamics of specific biomolecules and their interactions in real time in vivo. In this article, recent advances in OMI are reviewed extensively, such as the development of molecular probes that make imaging brighter, more stable and more informative (e.g., FPs and semiconductor nanocrystals, also referred to as quantum dots), the development of imaging approaches that provide higher resolution and greater tissue penetration, and applications for measuring biological events from molecule to organism level, including gene expression, protein and subcellular compartment localization, protein activation and interaction, and low-mass molecule dynamics. These advances are of great significance in the field of biological science and could also be applied to disease diagnosis and pharmaceutical screening. Further developments in OMI for systems biology are also proposed. © Springer-Verlag 2006.
KeywordFluorescent protein Optical molecular imaging Quantum dots Review Systems biology
URLView the original
Fulltext Access
Citation statistics
Cited Times [WOS]:53   [WOS Record]     [Related Records in WOS]
Document TypeJournal article
CollectionUniversity of Macau
AffiliationHuazhong University of Science and Technology
Recommended Citation
GB/T 7714
Du W.,Wang Y.,Luo Q.,et al. Optical molecular imaging for systems biology: From molecule to organism[J]. Analytical and Bioanalytical Chemistry,2006,386(3):444-457.
APA Du W.,Wang Y.,Luo Q.,&Liu B.-F..(2006).Optical molecular imaging for systems biology: From molecule to organism.Analytical and Bioanalytical Chemistry,386(3),444-457.
MLA Du W.,et al."Optical molecular imaging for systems biology: From molecule to organism".Analytical and Bioanalytical Chemistry 386.3(2006):444-457.
Related Services
Recommend this item
Usage statistics
Export to Endnote
Google Scholar
Similar articles in Google Scholar
[Du W.]'s Articles
[Wang Y.]'s Articles
[Luo Q.]'s Articles
Baidu academic
Similar articles in Baidu academic
[Du W.]'s Articles
[Wang Y.]'s Articles
[Luo Q.]'s Articles
Bing Scholar
Similar articles in Bing Scholar
[Du W.]'s Articles
[Wang Y.]'s Articles
[Luo Q.]'s Articles
Terms of Use
No data!
Social Bookmark/Share
All comments (0)
No comment.

Items in the repository are protected by copyright, with all rights reserved, unless otherwise indicated.